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Titolo:
Is there a role for agonist gastrin-releasing peptide receptor radioligands in tumour imaging?
Autore:
Van de Wiele, C; Dumont, F; Van Belle, S; Slegers, G; Peers, SH; Dierckx, RA;
Indirizzi:
State Univ Ghent Hosp, Div Nucl Med, B-9000 Ghent, Belgium State Univ Ghent Hosp Ghent Belgium B-9000 cl Med, B-9000 Ghent, Belgium
Titolo Testata:
NUCLEAR MEDICINE COMMUNICATIONS
fascicolo: 1, volume: 22, anno: 2001,
pagine: 5 - 15
SICI:
0143-3636(200101)22:1<5:ITARFA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMALL-CELL LUNG; SOMATOSTATIN ANALOG RC-160; BOMBESIN-LIKE PEPTIDES; HUMAN BREAST-CANCER; HIGH-AFFINITY RECEPTORS; HUMAN COLON-CANCER; SWISS 3T3 CELLS; PC-3 PROSTATE-CANCER; NUDE-MICE; ANTAGONIST RC-3095;
Keywords:
gastrin-releasing peptide; bombesin-like peptide; receptor ligands; tumour imaging;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
120
Recensione:
Indirizzi per estratti:
Indirizzo: Van de Wiele, C State Univ Ghent Hosp, Div Nucl Med, Pintelaan 185, B-9000Ghent, Belgium State Univ Ghent Hosp Pintelaan 185 Ghent Belgium B-9000
Citazione:
C. Van de Wiele et al., "Is there a role for agonist gastrin-releasing peptide receptor radioligands in tumour imaging?", NUCL MED C, 22(1), 2001, pp. 5-15

Abstract

Gastrin-releasing peptide (GRP) has been shown to be a tumour growth stimulating agent for a number of normal and human cancer cell lines. The tumourgrowth effect is a direct result of GRP binding to membrane G-protein coupled GRP receptors (GRP-R) on the cell surface. Available data on the role of GRP and CRP-R in human lung, prostate, breast, colorectal and gastric carcinoma are reviewed and it is suggested that radiolabelled agonists are preferable to antagonists for imaging and therapy as they appear to be internalised, yielding a higher target/background ratio. The use of rhenium or indium radiolabels for therapy may provide a new approach to GRP/bombesin expressing tumours. ((C) 2001 Lippincott Williams & Wilkins).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 17:03:44