Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Lack of effect of induction of hypothermia after acute brain injury.
Autore:
Clifton, GL; Miller, ER; Choi, SC; Levin, HS; McCauley, S; Smith, KR; Muizelaar, JP; Wagner, FC; Marion, DW; Luerssen, TG; Chesnut, RM; Schwartz, M;
Indirizzi:
Univ Texas, Hlth Sci Ctr, Sch Med, Dept Neurosurg,Vivian L Smith Ctr Neurol Res, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 ith Ctr Neurol Res, Houston, TX 77030 USA Virginia Commonwealth Univ, Med Coll Virginia, Dept Biostat, Richmond, VA 23298 USA Virginia Commonwealth Univ Richmond VA USA 23298 , Richmond, VA 23298 USA Virginia Commonwealth Univ, Med Coll Virginia, Dept Neurosurg, Richmond, VA 23298 USA Virginia Commonwealth Univ Richmond VA USA 23298 , Richmond, VA 23298 USA Baylor Coll Med, Dept Phys Med & Rehabil, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 Med & Rehabil, Houston, TX 77030 USA St Louis Univ, Dept Neurosurg, St Louis, MO 63103 USA St Louis Univ St Louis MO USA 63103 ept Neurosurg, St Louis, MO 63103 USA Univ Calif Davis, Dept Neurol Surg, Sacramento, CA 95817 USA Univ Calif Davis Sacramento CA USA 95817 l Surg, Sacramento, CA 95817 USA Univ Pittsburgh, Dept Neurosurg, Brain Trauma Res Ctr, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA ain Trauma Res Ctr, Pittsburgh, PA USA Indiana Univ, Div Neurosurg, Indianapolis, IN 46204 USA Indiana Univ Indianapolis IN USA 46204 rosurg, Indianapolis, IN 46204 USA Oregon Hlth Sci Univ, Dept Neurosurg, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 rosurg, Portland, OR 97201 USA Univ Toronto, Sunnybrook Med Ctr, Dept Neurosurg, Toronto, ON M4N 3M5, Canada Univ Toronto Toronto ON Canada M4N 3M5 osurg, Toronto, ON M4N 3M5, Canada
Titolo Testata:
NEW ENGLAND JOURNAL OF MEDICINE
fascicolo: 8, volume: 344, anno: 2001,
pagine: 556 - 563
SICI:
0028-4793(20010222)344:8<556:LOEOIO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEVERE HEAD-INJURY; INTRACRANIAL HYPERTENSION; MODERATE HYPOTHERMIA; MILD HYPOTHERMIA; PRESSURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Clifton, GL Univ Texas, Hlth Sci Ctr, Sch Med, Dept Neurosurg,Vivian L Smith Ctr Neurol Res, 6431 Fannin,Suite 7-148, Houston, TX 77030 USA Univ Texas 6431 Fannin,Suite 7-148 Houston TX USA 77030 30 USA
Citazione:
G.L. Clifton et al., "Lack of effect of induction of hypothermia after acute brain injury.", N ENG J MED, 344(8), 2001, pp. 556-563

Abstract

Background: Induction of hypothermia in patients with brain injury was shown to improve outcomes in small clinical studies, but the results were not definitive. To study this issue, we conducted a multicenter trial comparingthe effects of hypothermia with those of normothermia in patients with acute brain injury. Methods: The study subjects were 392 patients 16 to 65 years of age with coma after sustaining closed head injuries who were randomly assigned to be treated with hypothermia (body temperature, 33 degreesC), which was initiated within 6 hours after injury and maintained for 48 hours by means of surface cooling, or normothermia. All patients otherwise received standard treatment. The primary outcome measure was functional status six months after the injury. Results: The mean age of the patients and the type and severity of injury in the two treatment groups were similar. The mean (+/-SD) time from injuryto randomization was 4.3+/-1.1 hours in the hypothermia group and 4.1+/-1.2 hours in the normothermia group, and the mean time from injury to the achievement of the target temperature of 33 degreesC in the hypothermia group was 8.4+/-3.0 hours. The outcome was poor (defined as severe disability, a vegetative state, or death) in 57 percent of the patients in both groups. Mortality was 28 percent in the hypothermia group and 27 percent in the normothermia group (P=0.79). The patients in the hypothermia group had more hospital days with complications than the patients in the normothermia group. Fewer patients in the hypothermia group had high intracranial pressure thanin the normothermia group. Conclusions: Treatment with hypothermia, with the body temperature reaching 33 degreesC within eight hours after injury, is not effective in improving outcomes in patients with severe brain injury. (N Engl J Med 2001;344:556-63. ) Copyright (C) 2001 Massachusetts Medical Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 00:10:06