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Titolo:
Antenatal betamethasone treatment reduces synaptophysin immunoreactivity in presynaptic terminals in the fetal sheep brain
Autore:
Antonow-Schlorke, I; Kuhn, B; Muller, T; Schubert, H; Sliwka, U; Nathanielsz, PW; Schwab, M;
Indirizzi:
Univ Jena, Dept Neurol, D-07740 Jena, Germany Univ Jena Jena Germany D-07740 Jena, Dept Neurol, D-07740 Jena, Germany Univ Jena, Inst Lab Anim Sci, D-07740 Jena, Germany Univ Jena Jena Germany D-07740 Inst Lab Anim Sci, D-07740 Jena, Germany Cornell Univ, Coll Vet Med, Lab Pregnancy & Newborn Res, Ithaca, NY 14853 USA Cornell Univ Ithaca NY USA 14853 ancy & Newborn Res, Ithaca, NY 14853 USA
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 3, volume: 297, anno: 2001,
pagine: 147 - 150
SICI:
0304-3940(20010119)297:3<147:ABTRSI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUCOCORTICOID RECEPTORS; HUMAN NEOCORTEX; MEMBRANE; DEXAMETHASONE; ENDOCRINE; VESICLES; PROTEIN;
Keywords:
synaptophysin; antenatal glucocorticoids; betamethasone; fetal sheep;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Schwab, M Univ Jena, Dept Neurol, D-07740 Jena, Germany Univ Jena Jena Germany D-07740 t Neurol, D-07740 Jena, Germany
Citazione:
I. Antonow-Schlorke et al., "Antenatal betamethasone treatment reduces synaptophysin immunoreactivity in presynaptic terminals in the fetal sheep brain", NEUROSCI L, 297(3), 2001, pp. 147-150

Abstract

Knowledge of morphofunctional effects on the fetal brain induced by exogenous glucocorticoids is limited. Recently, we reported alterations of both the neuronal cytoskeleton and electrocortical function in the ovine fetal brain after antenatal betamethasone treatment in doses used in perinatal medicine. In the present study we examined whether these changes are accompanied by morphological alterations of synapses. Chronically instrumented fetal sheep at 0.87 of gestation were treated either with isotonic saline (n = 7)or 10 mug/h betamethasone (n = 7) over 48 h administered directly to the fetal jugular vein. Paraffin sections of the frontal neocortex, caudate putamen and hippocampus were stained with a monoclonal antibody against synaptophysin, a specific membrane protein of presynaptic vesicles and quantified morphometrically. Synaptophysin-like immunoreactivity (synaptophysin-LI) showed a widespread granular pattern in the neuropil. Betamethasone exposure reduced synaptophysin-ll in the frontal neocortex, caudate putamen and hippocampus by 46.9, 41.0 and 55.4%, respectively, (P < 0.05) that was not accompanied by irreversible neuronal damage. These results suggest that clinical doses of betamethasone have acute effects on presynaptic terminals in thefetal sheep brain that could contribute to the altered complexity of electrocortical function that we have shown previously to occur following fetal exposure to betamethasone. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 15:46:27