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Titolo:
Modulation by lanthanum ions of gamma-aminobutyric acid(A) receptors of rat cerebellum granule cells in culture: clues on their subunit composition
Autore:
Barila, B; Cupello, A; Robello, M;
Indirizzi:
Univ Genoa, Dipartimento Fis, INFM, I-16146 Genoa, Italy Univ Genoa Genoa Italy I-16146 artimento Fis, INFM, I-16146 Genoa, Italy CNR, Ctr Neurofisiol Cerebrale, Genoa, Italy CNR Genoa ItalyCNR, Ctr Neurofisiol Cerebrale, Genoa, Italy
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1, volume: 298, anno: 2001,
pagine: 13 - 16
SICI:
0304-3940(20010126)298:1<13:MBLIOG>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
GABA(A) RECEPTORS; CURRENTS; NEURONS; ENHANCEMENT; ZN2+; RECOMBINANT; INHIBITION; SUBTYPES; ISOFORMS; ZINC;
Keywords:
cerebellum; granule cells; gamma-aminobutyric acid(A) receptors; lanthanum ions; patch-clamp; receptor heterogeneity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Robello, M Univ Genoa, Dipartimento Fis, INFM, Via Dodecaneso 33, I-16146 Genoa, Italy Univ Genoa Via Dodecaneso 33 Genoa Italy I-16146 Genoa, Italy
Citazione:
B. Barila et al., "Modulation by lanthanum ions of gamma-aminobutyric acid(A) receptors of rat cerebellum granule cells in culture: clues on their subunit composition", NEUROSCI L, 298(1), 2001, pp. 13-16

Abstract

gamma -Aminobutyric acid (GABA) activated chloride currents were studied in rat cerebellum granule cells in culture by the whole cell patch-clamp technique. Both the peak and steady state currents were inhibited by 100 muM lanthanum. in the fi rst case, inhibition is due to an increase of the ECS, for GABA. The inhibitory effect of lanthanum on the peak current at 3 muM GABA increased with the cation concentration. A tendency towards the same behavior was found also for the inhibition of the steady state current, at 3 muM GABA, as a function of lanthanum concentration, although inhibition in this case was lower. The comparison of the results with published data about the effects of lanthanum on recombinant GABAA receptors likely to occur in granule cells allows suggestions about the receptor types giving, respectively, the peak and the steady state component. (C) 2001 Published by Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 09:02:01