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Titolo:
Three different human tau isoforms and rat neurofilament light, middle andheavy chain proteins are cellular substrates for transglutaminase
Autore:
Grierson, AJ; Johnson, GVW; Miller, CCJ;
Indirizzi:
Inst Psychiat, Dept Neurosci, London SE5 8AF, England Inst Psychiat London England SE5 8AF t Neurosci, London SE5 8AF, England Inst Psychiat, Dept Neurol, London SE5 8AF, England Inst Psychiat LondonEngland SE5 8AF ept Neurol, London SE5 8AF, England Univ Alabama, Dept Psychiat, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 t Psychiat, Birmingham, AL 35294 USA
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1, volume: 298, anno: 2001,
pagine: 9 - 12
SICI:
0304-3940(20010126)298:1<9:TDHTIA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALZHEIMERS-DISEASE; TISSUE TRANSGLUTAMINASE; IN-SITU; FILAMENTS; CELLS; BRAIN;
Keywords:
tau; neurofilaments; transglutaminase; Alzheimer's disease; motor neurone disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Miller, CCJ Inst Psychiat, Dept Neurosci, De Crespigny Pk,Denmark Hill, London SE5 8AF, England Inst Psychiat De Crespigny Pk,Denmark Hill London England SE5 8AF
Citazione:
A.J. Grierson et al., "Three different human tau isoforms and rat neurofilament light, middle andheavy chain proteins are cellular substrates for transglutaminase", NEUROSCI L, 298(1), 2001, pp. 9-12

Abstract

Abnormal aggregates of tau and neurofilaments are pathologies of Alzheimer's disease. Some of these aggregates are insoluble in chaotropic salts and ionic detergents but the mechanisms that lead to this are not clear. One suggestion is that it is due to crosslinking by tissue transglutaminase. Bothtau and neurofilaments can be crosslinked by transglutaminase in vitro andone isoform of tau is now known to be a cellular transglutaminase substrate. However there is no evidence to demonstrate that neurofilaments are cellular substrates for transglutaminase and it is not clear whether other isoforms of tau are equally susceptible to transglutaminase crosslinking. Here,we demonstrate that three different tau isoforms and neurofilament light, middle and heavy chain proteins are all cellular substrates for transglutaminase. (C) 2001 Published by Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:40:31