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Titolo:
No functional effects of embryonic neuronal grafts on motor deficits in a 3-nitropropionic acid rat model of advanced striatonigral degeneration (multiple system atrophy)
Autore:
Waldner, R; Puschban, Z; Scherfler, C; Seppi, K; Jellinger, K; Poewe, W; Wenning, GK;
Indirizzi:
Univ Innsbruck Hosp, Neurol Res Lab, Dept Neurol, A-6020 Innsbruck, Austria Univ Innsbruck Hosp Innsbruck Austria A-6020 , A-6020 Innsbruck, Austria Ludwig Boltzmann Inst Clin Neurobiol, A-1140 Vienna, Austria Ludwig Boltzmann Inst Clin Neurobiol Vienna Austria A-1140 enna, Austria
Titolo Testata:
NEUROSCIENCE
fascicolo: 3, volume: 102, anno: 2001,
pagine: 581 - 592
SICI:
0306-4522(2001)102:3<581:NFEOEN>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESENCEPHALIC DOPAMINERGIC-NEURONS; PROGRESSIVE SUPRANUCLEAR PALSY; UNILATERAL NEOSTRIATAL LESIONS; STRIATAL GRAFTS; HUNTINGTONS-DISEASE; PARKINSONS-DISEASE; EFFERENT PROJECTIONS; TRANSPLANTATION; ABNORMALITIES; SURVIVAL;
Keywords:
mesencephalic graft; striatal graft; co-graft; rotation; staircase test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Wenning, GK Univ Innsbruck Hosp, Neurol Res Lab, Dept Neurol, Anichstr 35,A-6020 Innsbruck, Austria Univ Innsbruck Hosp Anichstr 35 Innsbruck Austria A-6020 tria
Citazione:
R. Waldner et al., "No functional effects of embryonic neuronal grafts on motor deficits in a 3-nitropropionic acid rat model of advanced striatonigral degeneration (multiple system atrophy)", NEUROSCIENC, 102(3), 2001, pp. 581-592

Abstract

lntrastriatal injection of 3-nitropropionic acid results in secondary excitotoxic local damage and retrograde neuronal cell loss in substantia nigra pars compacta, thus mimicking salient features of striatonigral degeneration, the core pathology underlying Parkinsonism associated with multiple system atrophy. We used 3-nitropropionic acid to create a rat model of advancedstriatonigral degeneration in order to assess the effects of embryonic allografts upon rotational and complex-motor behavioural abnormalities. Following stereotaxic intrastriatal administration of 500 nmol 3-nitropropionic acid in male Wistar rats we observed consistent amphetamine- and apomorphine-induced ipsiversive rotation. Furthermore, there were marked deficits of contralateral paw reaching. Subsequently, animals received intrastriatal implantations of either E14 mesencephalic or striatal or mixed embryonic cell suspensions. In addition, one group received sham injections. Grafted rats were followed for up to 21 weeks and repeated behavioural tests were obtained during this period. Drug-induced rotation asymmetries and complex motor deficits measured by paw reaching tests were not compensated by embryonic grafts. persistence of drug-induced rotations and of paw reaching deficits following transplantation probably reflects severe atrophy of adult striatum, additional nigral degeneration as well as glial demarcation of embryonic grafts. We suggest that dopamine rich embryonic grafts fail to induce functional recovery in a novel 3-nitropropionic acid rat model of advanced striatonigral degeneration (multiple system atrophy). (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

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Documento generato il 28/01/20 alle ore 20:56:23