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Titolo:
Nociceptin/orphanin FQ regulates neuroendocrine function of the limbic-hypothalamic-pituitary-adrenal axis
Autore:
Devine, DP; Watson, SJ; Akil, H;
Indirizzi:
Univ Florida, Dept Psychol, Gainesville, FL 32611 USA Univ Florida Gainesville FL USA 32611 Psychol, Gainesville, FL 32611 USA Univ Michigan, Mental Hlth Res Inst, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 th Res Inst, Ann Arbor, MI 48109 USA
Titolo Testata:
NEUROSCIENCE
fascicolo: 3, volume: 102, anno: 2001,
pagine: 541 - 553
SICI:
0306-4522(2001)102:3<541:NFRNFO>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; PROTEIN-COUPLED RECEPTOR; GAMMA-S BINDING; ORPHANIN-FQ; MESSENGER-RNA; MOLECULAR-CLONING; ORL1 RECEPTOR; RAT-BRAIN; CORTICOSTERONE SECRETION; GLUCOCORTICOID RECEPTORS;
Keywords:
orphanin FQ; nociceptin; stress; adrenocorticotrophic hormone; corticosterone; anxiety;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
97
Recensione:
Indirizzi per estratti:
Indirizzo: Devine, DP Univ Florida, Dept Psychol, POB 112250, Gainesville, FL 32611 USA Univ Florida POB 112250 Gainesville FL USA 32611 , FL 32611 USA
Citazione:
D.P. Devine et al., "Nociceptin/orphanin FQ regulates neuroendocrine function of the limbic-hypothalamic-pituitary-adrenal axis", NEUROSCIENC, 102(3), 2001, pp. 541-553

Abstract

We examined the effects of the neuropeptide nociceptin/orphanin FQ on activity of the limbic-hypothalamic-pituitary-adrenal axis (also known as the stress axis) in rats. This axis regulates important metabolic functions, andinitiates critical neuroendocrine responses that cope with environmental threats and challenges to homeostatic functioning. Disregulation of the limbic-hypothalamic-pituitary-adrenal axis is associated with impaired physicaland psychological health. In the present experiments. rats were treated with intracerebroventricular injections of nociceptin/orphanin FQ in the presence or absence of acute stressors. Plasma adrenocorticotrophic hormone andcorticosterone concentrations were assayed 15 or 30 min after injections. In the rats that were not exposed to stress, nociceptin/orphanin FQ produced dose-orderly elevations of circulating adrenocorticotrophic hormone and corticosterone concentrations. These effects were also found after administration of the nociceptin/orphanin FQ analogues, des-Phe orphanin FQ and [Phe(1)psi (CH2-NH)Gly(2)] nociceptin((1-13))NH(2). In rats that were exposed to the mild stress of a novel environment, nociceptin/orphanin FQ administration enhanced the stress-induced elevations of plasma adrenocorticotrophic hormone concentrations and prolonged the stress-induced elevations of plasma corticosterone concentrations. In rats that were exposed to restraint stress, nociceptin/ orphanin FQ administration did not augment the stress-induced elevations in plasma hormones, perhaps because of a ceiling effect. We conclude that administration of nociceptin/orphanin FQ activates neuroendocrine activity of the limbic-hypothalamic-pituitary-adrenal axis even inthe absence of a stressor, and map delay the shutdown of these physiological responses after exposure to acute mild stress. In light of the known functions of this axis, it appears that nociceptin/orphanin FQ participates inthe regulation of important metabolic functions, and may be implicated in physiological responses to stress. This interaction between nociceptin/orphanin FQ and the limbic-hypothalamic-pituitary-adrenal axis implicates nociceptin/orphanin FQ in important aspects of physiological and psychological well-being. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 20:11:17