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Titolo:
Glycine reduces novelty- and methamphetamine-induced locomotor activity inneonatal ventral hippocampal damaged rats
Autore:
Kato, K; Shishido, T; Ono, M; Shishido, K; Kobayashi, M; Niwa, S;
Indirizzi:
Fukushima Med Univ, Sch Med, Dept Neuropsychiat, Fukushima 9601295, Japan Fukushima Med Univ Fukushima Japan 9601295 iat, Fukushima 9601295, Japan
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 3, volume: 24, anno: 2001,
pagine: 330 - 332
SICI:
0893-133X(200103)24:3<330:GRNAML>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEGATIVE SYMPTOMS; SCHIZOPHRENIA; MODEL;
Keywords:
schizophrenia; hippocampus; animal models; glycine; methamphetamine; ibotenic acid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Kato, K Fukushima Med Univ, Sch Med, Dept Neuropsychiat, 1 Hikarigaoka, Fukushima 9601295, Japan Fukushima Med Univ 1 Hikarigaoka Fukushima Japan 9601295 5, Japan
Citazione:
K. Kato et al., "Glycine reduces novelty- and methamphetamine-induced locomotor activity inneonatal ventral hippocampal damaged rats", NEUROPSYCH, 24(3), 2001, pp. 330-332

Abstract

The use of neonatal ventral hippocampal nVH lesioned rats is well established in animal models of schizophrenia. Moreover, the dysfunction of N-methyl-D-aspartate (NMDA) neurotransmission may play a crucial role in the pathophysiology of schizophrenia. To examine the effect of glycine (GLY) in thisanimal model, we compared the effects of GLY (0.8 and 1.6 g/kg, IP) on locomotor activity induced by a novel environment (NOVEL) and methamphetamine (MAP, 1.5 mg/kg, IF) in lesioned and sham-operated rats. Compared with shamrats, GLY significantly reduced NOVEL- and MAP-induced locomotor activity in lesioned mts (p < .001 and p < .05, respectively). It is suggested that GLY attenuated nVH-induced hyperactivity, and that this effect was evident both in the presence and absence of MAP. The nVH lesions may result in a form of hyperactivity that differs from normal locomotion in the degree to which it is highly sensitive to regulation by GLY. (C) 2001 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 10:29:11