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Titolo:
Role of 5-HT2A and 5-HT2B/2C receptors in the behavioral interactions between serotonin and catecholamine reuptake inhibitors
Autore:
McMahon, LR; Cunningham, KA;
Indirizzi:
Univ Texas, Med Branch, Dept Pharmacol & Toxicol, Galveston, TX 77555 USA Univ Texas Galveston TX USA 77555 acol & Toxicol, Galveston, TX 77555 USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 3, volume: 24, anno: 2001,
pagine: 319 - 329
SICI:
0893-133X(200103)24:3<319:RO5A5R>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED LOCOMOTOR-ACTIVITY; VENTRAL TEGMENTAL AREA; IN-VIVO MICRODIALYSIS; FREELY-MOVING RATS; DOPAMINE RELEASE; NUCLEUS-ACCUMBENS; PHARMACOLOGICAL CHARACTERIZATION; ANTAGONIST MDL-100,907; EXTRACELLULAR DOPAMINE; SELECTIVE BLOCKADE;
Keywords:
dopamine; locomotor activity; serotonin; 5-HT2A receptors; 5-HT2C receptors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Cunningham, KA Univ Texas, Med Branch, Dept Pharmacol & Toxicol, Galveston, TX 77555 USA Univ Texas Galveston TX USA 77555 Galveston, TX 77555 USA
Citazione:
L.R. McMahon e K.A. Cunningham, "Role of 5-HT2A and 5-HT2B/2C receptors in the behavioral interactions between serotonin and catecholamine reuptake inhibitors", NEUROPSYCH, 24(3), 2001, pp. 319-329

Abstract

Dysfunction of monoamine neurotransmission seems to contribute to such pathopsychological states as depression, schizophrenia, and drug abuse. The present study examined the effects of the selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitor (SSRI) and antidepressant fluvoxamine on locomotor activity in rats following administration of the catecholamine reuptake inhibitor mazindol. Mazindol (I mg/kg) did not alter locomotor activity; whereas, fluvoxamine (20 mg/kg) given alone induced it brief period of hypomotility. Hyperactivity was elicited in a dose-related manner when fluvoxamine (5-20 mg/kg) was combined with mazindol (I mg/kg). The hyperactivityelicited by fluvoxamine (20 mg/kg) plus mazindol (I mg/kg) was significantly attenuated by the 5-HT2A receptor antagonist M100907 (2 mg/kg) and potentiated by the 5-HT2B/2C receptor antagonist SE 206553 (2 mg/kg). Neither antagonist significantly altered basal activity. The hyperactivity evoked by the combination of fluvoxamine and mazindol seems to be mediated in part by5-HT2A receptors; whereas, 5-HT2B/2C receptors may serve to limit this effect. Thus, the balance of activation between 5-HT2A and 5-HT2B/2C receptorsseems to contribute to the expression of locomotor hyperactivity evoked via combination of a 5-HT and a catecholamine reuptake inhibitor. A disruption in this balance may contribute to the expression of affective disorders, schizophrenia, and drug abuse. (C) 2001 American College of Neuropsychopharmacology. Published by Elseiver Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:44:50