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Titolo:
Expression of AMPA receptor flip and flop mRNAs in the nucleus accumbens and prefrontal cortex after neonatal ventral hippocampal lesions
Autore:
Stine, CD; Lu, WX; Wolf, ME;
Indirizzi:
Finch Univ Hlth Sci Chicago Med Sch, Dept Neurosci, N Chicago, IL 60064 USA Finch Univ Hlth Sci Chicago Med Sch N Chicago IL USA 60064 , IL 60064 USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 3, volume: 24, anno: 2001,
pagine: 253 - 266
SICI:
0893-133X(200103)24:3<253:EOARFA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMPHETAMINE ADMINISTRATION ALTERS; SELECTIVE GLUTAMATE RECEPTORS; MESSENGER-RNA EXPRESSION; LOCAL CIRCUIT NEURONS; IN-SITU HYBRIDIZATION; RAT-BRAIN; BASAL GANGLIA; ANTIPSYCHOTIC-DRUGS; SUBUNIT COMPOSITION; CHRONIC HALOPERIDOL;
Keywords:
alternative splicing; AMPA receptors; in situ hybridization; nucleus accumbens; prefrontal cortex; schizophrenia;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
111
Recensione:
Indirizzi per estratti:
Indirizzo: Wolf, ME Finch Univ Hlth Sci Chicago Med Sch, Dept Neurosci, 3333 Green Bay Rd, N Chicago, IL 60064 USA Finch Univ Hlth Sci Chicago Med Sch 3333 Green Bay Rd N Chicago IL USA 60064
Citazione:
C.D. Stine et al., "Expression of AMPA receptor flip and flop mRNAs in the nucleus accumbens and prefrontal cortex after neonatal ventral hippocampal lesions", NEUROPSYCH, 24(3), 2001, pp. 253-266

Abstract

Many lines of evidence implicate dysfunctional excitatory amino acid (EAA)transmission in schizophrenia. The present study examined alpha -amino-3-hydroxy-5-methylisoxazole-4-priopionate (AMPA) receptor expression in the prefrontal cortex (PFC) and nucleus accumbens (NAc) using a rat model of schizophrenia in which excitotoxic lesions of ventral hippocampus (VH) on postnatal day (PD) 7 lead to the postpubertal emergence of behavioral abnormalities that resemble schizophrenic symptoms. In situ hybridization histochemistry with S-35-labeled oligonucleotide probes was used to quantify mRNA levels for GluR1-3 flip and flop variants at prepubertal and postpubertal time-points (PD 35 and 60, respectively). Comparisons of PD 35 and PD 60 groups suggested that there may be changes in the relative expression of flip and flop isoforms during normal development. The most pronounced change was an apparent increase in the flip/flop ratio for GluR1 from PD 35 to PD 60 in both the PFC and the NAc. Neonatal VH lesions did not significantly alter GluR1-3 flip and flop mRNA levels in the NAc at either time-point. However, in the PFC, GluR3 flop mRNA levels were significantly decreased in lesioned mts at PD 60. AMPA receptors incorporating flop variants exhibit faster desensitization, so a shift forwards flip incorporation might lend to increased neuronal excitability in the PFC, thereby influencing subcortical DA systems regulated by PFC efferents. In summary, an early developmental injury can predispose rats to abnormal development of EAA transmission in the PFC. This may contribute to the postpubertal onset of symptoms after neonatal VHlesions. (C) 2001 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:42:41