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Titolo:
Effects of MDMA (ecstasy) on prepulse inhibition and habituation of startle in humans after pretreatment with citalopram, haloperidol, or ketanserin
Autore:
Liechti, ME; Geyer, MA; Hell, D; Vollenweider, FX;
Indirizzi:
Univ Zurich, Hosp Psychiat, CH-8029 Zurich, Switzerland Univ Zurich Zurich Switzerland CH-8029 hiat, CH-8029 Zurich, Switzerland Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA Univ Calif SanDiego La Jolla CA USA 92093 ychiat, La Jolla, CA 92093 USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 3, volume: 24, anno: 2001,
pagine: 240 - 252
SICI:
0893-133X(200103)24:3<240:EOM(OP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACOUSTIC STARTLE; 3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA; SCHIZOPHRENIC-PATIENTS; RECEPTOR MODULATION; MEDIATED RELEASE; 5-HT MODULATION; KNOCKOUT MICE; WISTAR RATS; REFLEX; SEROTONIN;
Keywords:
3,4-methylenedioxy-N-methylamphetamine; MDMA; ecstasy; serotonin; citalopram; haloperidol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Vollenweider, FX Univ Zurich, Hosp Psychiat, POB 68, CH-8029 Zurich, Switzerland Univ Zurich POB 68 Zurich Switzerland CH-8029 witzerland
Citazione:
M.E. Liechti et al., "Effects of MDMA (ecstasy) on prepulse inhibition and habituation of startle in humans after pretreatment with citalopram, haloperidol, or ketanserin", NEUROPSYCH, 24(3), 2001, pp. 240-252

Abstract

Prepulse inhibition (PPI) of the acoustic startle response is an operational measure of sensorimotor gating that can be assessed in animals and in humans. Serotonin releasers such as MDMA disrupt PPI and reduce startle habituation in rodents. These effects are prevented by pretreatment with selective serotonin uptake inhibitors, indicating that the effect of MDMA on startle plasticity is largely due to carrier-mediated release of serotonin from presynaptic terminals. In contrast, MDMA has been shown to increase PPI in humans. It is unclear, however, whether the MDMA-induced increase in PPI inhumans is also dependent on carrier-mediated serotonin release and which postsynaptic receptors are involved. We investigated the effects of three different pretreatments on the MDMA-induced effects on PPI and habituation inhumans. Pretreatments were: (1) the highly selective serotonin uptake inhibitor citalopram (40 mg IV) in 16 subjects, (2) the D-2 antagonist haloperidol (1.4 mg IV) in 24 subjects, and (3) the 5-HT2A/C antagonist ketanserin (50 mg PO) in 14 subjects. Each of the three studies used a double-blind placebo-controlled design. All healthy volunteers were examined four times at2-4-week intervals after placebo, pretreatment, MDMA (1.5 mg/kg PO), and pretreatment plus MDMA. MDMA increased PPI. Habituation was not altered by MDMA, although MDMA-induced individual differences on habituation and psychological symptoms were inversely correlated. Citalopram attenuated the MDMA-induced increase in PPI and most of the psychological effects of MDMA. Neither haloperidol nor ketanserin had any effect on PPI increases produced by MDMA, although each partially attenuated some MDMA-induced psychological effects. Results are consistent with the view that MDMA increases PPI of the acoustic startle reflex in humans via release of presynaptic serotonin. [Neuropsychopharmacology 24:240-252, 2001] (C) 2001 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/11/19 alle ore 02:54:24