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Titolo:
Functional consequences of repeated (+/-)3,4-methylenedioxymethamphetamine(MDMA) treatment in rhesus monkeys
Autore:
Taffe, MA; Weed, MR; Davis, S; Huitron-Resendiz, S; Schroeder, R; Parsons, LH; Henriksen, SJ; Gold, LH;
Indirizzi:
Scripps Clin & Res Inst, Dept Neuropharmacol, La Jolla, CA 92037 USA Scripps Clin & Res Inst La Jolla CA USA 92037 col, La Jolla, CA 92037 USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 3, volume: 24, anno: 2001,
pagine: 230 - 239
SICI:
0893-133X(200103)24:3<230:FCOR(>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL SEROTONERGIC NEURONS; POSITRON-EMISSION-TOMOGRAPHY; 3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA; RECREATIONAL USE; ECSTASY MDMA; METHYLENEDIOXYMETHAMPHETAMINE MDMA; OLIVOCOCHLEAR NEURONS; NONHUMAN-PRIMATES; MEMORY DEFICITS; SHORT-TERM;
Keywords:
ecstasy; MDMA; monkey; cognition; memory; evoked potential;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Taffe, MA Scripps Clin & Res Inst, Dept Neuropharmacol, CVN-7, La Jolla, CA 92037 USA Scripps Clin & Res Inst CVN-7 La Jolla CA USA 92037 CA 92037 USA
Citazione:
M.A. Taffe et al., "Functional consequences of repeated (+/-)3,4-methylenedioxymethamphetamine(MDMA) treatment in rhesus monkeys", NEUROPSYCH, 24(3), 2001, pp. 230-239

Abstract

Six rhesus monkeys were trained to stable performance on neuropsychological tests of memory, reinforcer efficacy, reaction time and bimanual motor coordination. Three monkeys were then exposed to a high-dose, short course regimen of (+/-)3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy" (4 days, 10 mg/kg i.m., b.i.d.). Following treatment, cotzcentrrrtions of 5-hydroxyindoleacetic acid (5-HIAA) in cerebrospinal fluid (CSF) were reduced by similar to 50% in the treated animals, and this effect persisted for approximately three months post-MDMA. Behavioral performance was disrupted during acute MDMA treatment but returned to baseline within one week following treatment. MDMA also produced persistent alterations in late peak latencies of brainstem auditory evoked potentials (BSAEP), lasting three months post-MDMA. Both CSF 5-HIAA concentrations and evoked potential latencies were normalized four months after treatment. These findings indicate that serotonergic alterations associated with MDMA use may result in persisting changes in brain function. (C) 2001 American College of Neuropsychopharmacology Publishedby EIsevier Science Inc.

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Documento generato il 26/01/20 alle ore 00:57:06