Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The COMT L allele modifies the association between MAOB polymorphism and PD in Taiwanese
Autore:
Wu, RM; Cheng, CW; Chen, KH; Lu, SL; Shen, DE; Ho, YF; Chern, HD;
Indirizzi:
Natl Taiwan Univ Hosp, Dept Neurol, Taipei 100, Taiwan Natl Taiwan Univ Hosp Taipei Taiwan 100 Dept Neurol, Taipei 100, Taiwan Natl Taiwan Univ, Coll Med, Dept Neurol, Taipei 10018, Taiwan Natl Taiwan Univ Taipei Taiwan 10018 , Dept Neurol, Taipei 10018, Taiwan Natl Taiwan Univ, Coll Med, Grad Inst Pharmaceut Sci, Taipei 10018, TaiwanNatl Taiwan Univ Taipei Taiwan 10018 harmaceut Sci, Taipei 10018, Taiwan Natl Taiwan Univ, Coll Publ Hlth, Inst Epidemiol, Taipei 10764, Taiwan Natl Taiwan Univ Taipei Taiwan 10764 nst Epidemiol, Taipei 10764, Taiwan Vet Gen Hosp, Neurol Inst, Taipei, Taiwan Vet Gen Hosp Taipei TaiwanVet Gen Hosp, Neurol Inst, Taipei, Taiwan Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan Natl Yang Ming Univ Taipei Taiwan 112 Univ, Sch Med, Taipei 112, Taiwan
Titolo Testata:
NEUROLOGY
fascicolo: 3, volume: 56, anno: 2001,
pagine: 375 - 382
SICI:
0028-3878(20010213)56:3<375:TCLAMT>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOAMINE-OXIDASE-B; CATECHOL-O-METHYLTRANSFERASE; PARKINSONS-DISEASE; GENE; SUSCEPTIBILITY; POPULATION; MPTP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Wu, RM Natl Taiwan Univ Hosp, Dept Neurol, 7 Chung Shan S Rd, Taipei 100, Taiwan Natl Taiwan Univ Hosp 7 Chung Shan S Rd Taipei Taiwan 100 , Taiwan
Citazione:
R.M. Wu et al., "The COMT L allele modifies the association between MAOB polymorphism and PD in Taiwanese", NEUROLOGY, 56(3), 2001, pp. 375-382

Abstract

Objective: Reports suggest that catechol-O-methyltransferase (COMTL/L) (Val(158)/Met) and monoamine oxidase B (MAOB) intron 13 genotype polymorphism is associated with PD. To understand the ethnicity-specific effects of genetic polymorphism, we performed a case-control study of the association between PD susceptibility and polymorphism of MAOB and COMT, both separately and in combination, in Taiwanese. Methods: Two hundred twenty-four patients with PD and 197 controls, matched for age, sex, and birthplace, were recruited. MAOB and COMT polymorphism genotyping was performed by using PCR-based restriction fragment length polymorphism (RFLP) analyses. chi (2), OR, and Fisher's exact tests were used to compare differences in allelic frequencies and genotypes. Results: The MAOB G genotype (G in men and GIG in women) was associated with a 2.07-fold increased relative risk of PD. COMT polymorphism, considered alone, showed no correlation with PD risk; however, a significant synergistic enhancement was found in PD patients harboring both theCOMTL and MAOB G genotypes. Conclusions: These results suggest that, in Taiwanese, PD risk is associated with MAOB G intron 13 polymorphism, and thisassociation is augmented in the presence of the COMTL genotype, indicatingan interaction of these two dopamine-metabolizing enzymes in the pathogenesis of sporadic PD. However, the relatively low frequencies of these combined genotypes in our study necessitates confirmation with a larger sample size.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 11:14:43