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Titolo:
APOE genotype is a major predictor of long-term progression of disability in MS
Autore:
Chapman, J; Vinokurov, S; Achiron, A; Karussis, DM; Mitosek-Szewczyk, K; Birnbaum, M; Michaelson, DM; Korczyn, AD;
Indirizzi:
Sackler Fac Med, Dept Neurol, Tel Aviv, Israel Sackler Fac Med Tel Aviv Israel Fac Med, Dept Neurol, Tel Aviv, Israel Sackler Fac Med, Dept Physiol & Pharmacol, Tel Aviv, Israel Sackler Fac Med Tel Aviv Israel t Physiol & Pharmacol, Tel Aviv, Israel Sackler Fac Med, Dept Biochem, Tel Aviv, Israel Sackler Fac Med Tel AvivIsrael Fac Med, Dept Biochem, Tel Aviv, Israel Tel Aviv Med Ctr, Dept Neurol, Tel Aviv, Israel Tel Aviv Med Ctr Tel Aviv Israel Med Ctr, Dept Neurol, Tel Aviv, Israel Tel Aviv Med Ctr, Neuroimmunol Clin, Tel Aviv, Israel Tel Aviv Med Ctr Tel Aviv Israel r, Neuroimmunol Clin, Tel Aviv, Israel Chaim Sheba Med Ctr, Neuroimmunol Unit, Tel Aviv, Israel Chaim Sheba Med Ctr Tel Aviv Israel Neuroimmunol Unit, Tel Aviv, Israel Tel Aviv Univ, Dept Neurobiochem & Life Sci, IL-69978 Tel Aviv, Israel TelAviv Univ Tel Aviv Israel IL-69978 fe Sci, IL-69978 Tel Aviv, Israel Hadassah Med Ctr, Dept Neurol, IL-91120 Jerusalem, Israel Hadassah Med Ctr Jerusalem Israel IL-91120 l, IL-91120 Jerusalem, Israel Sch Med, Teaching Dept Neurol, Lublin, Poland Sch Med Lublin PolandSch Med, Teaching Dept Neurol, Lublin, Poland
Titolo Testata:
NEUROLOGY
fascicolo: 3, volume: 56, anno: 2001,
pagine: 312 - 316
SICI:
0028-3878(20010213)56:3<312:AGIAMP>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLE-SCLEROSIS; APOLIPOPROTEIN-E; EPSILON-4 ALLELE; ALZHEIMERS-DISEASE; NATURAL-HISTORY; DEMENTIA; ONSET; AGE; APOE-EPSILON-4; FREQUENCY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Korczyn, AD Tel Aviv Univ, Sierazki Chair Neurol, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 9978 Tel Aviv, Israel
Citazione:
J. Chapman et al., "APOE genotype is a major predictor of long-term progression of disability in MS", NEUROLOGY, 56(3), 2001, pp. 312-316

Abstract

Background and objective: The authors recently reported that the APOE epsilon4 allele is associated with significantly greater progression of disability in a 2-year follow-up of patients with MS. In this study, these findings are substantiated and extended in a much larger group of patients followed for up to 40 years. Methods: Two hundred five patients with clinically definite MS who were genotyped for the APOE epsilon4 carrier state were included. Groups of patients with (n = 41) and without (n = 164) APOE epsilon4 alleles were compared for latency to expanded disability status scale (EDSS)scores of 4.0 and 6.0 by Kaplan-Meier analysis with the log rank test. Theresults were adjusted for age at onset and sex by Cox regression analysis. Results: The APOE epsilon4 allele frequency in patients with MS (0.10) wassimilar to that in the general Israeli population. There was a significanteffect of APOE genotype on the latency to reach EDSS 4.0 and 6.0 (p = 0.0002 and p = 0.0006 by two-tailed log rank test). Median latencies were shorter by 12 and 11 years in the APOE epsilon4 group for these outcomes. These results were significant after adjustment for age at onset and sex. Conclusions: The APOE epsilon4 allele is associated with significantly faster progression of disability in MS. This is the first genetic factor to be identified with a major impact on the progression of disability in this disease.

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Documento generato il 09/08/20 alle ore 06:08:57