Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The functionally important IL-10 promoter polymorphism (-1082G -> A) is not a major genetic regulator in recurrent spontaneous abortions
Autore:
Karhakorpi, J; Laitinen, T; Karttunen, R; Tiilikainen, AS;
Indirizzi:
Univ Oulu, Dept Med Microbiol, Oulu 90014, Finland Univ Oulu Oulu Finland 90014 lu, Dept Med Microbiol, Oulu 90014, Finland Finnish Red Cross & Blood Transfus Serv, Tissue Typing Lab, SF-00310 Helsinki, Finland Finnish Red Cross & Blood Transfus Serv Helsinki Finland SF-00310 inland
Titolo Testata:
MOLECULAR HUMAN REPRODUCTION
fascicolo: 2, volume: 7, anno: 2001,
pagine: 201 - 203
SICI:
1360-9947(200102)7:2<201:TFIIPP>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERLEUKIN-10 GENE; CYTOKINE PRODUCTION; HUMAN-PREGNANCY; TNF-ALPHA; MISCARRIAGE; ANTIGENS; COUPLES; WOMEN; CELLS;
Keywords:
abortion; IL-10; polymorphism; pregnancy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Karhakorpi, J Univ Oulu, Dept Med Microbiol, POB 5000, Oulu 90014, FinlandUniv Oulu POB 5000 Oulu Finland 90014 , Oulu 90014, Finland
Citazione:
J. Karhakorpi et al., "The functionally important IL-10 promoter polymorphism (-1082G -> A) is not a major genetic regulator in recurrent spontaneous abortions", MOL HUM REP, 7(2), 2001, pp. 201-203

Abstract

Enhanced secretion of anti-inflammatory Th2 cytokines is a characteristic feature in normal physiological pregnancy. In recurrent spontaneous abortions (RSA), however, defective production of interleukin-10 (IL-10) and otherTh2 cytokines has been shown in humans. Association studies have shown that a base exchange polymorphism (guanine-->adenine) at position -1082 of theIL-10 promoter is associated with differential IL-10 production. Since factors contributing. to IL-10 production appear to be important in RSA, we studied the IL-10 genotypes of 38 Finnish women with a history of three or more consecutive abortions and 131 ethnically matched healthy controls. No significant differences in the -1082 allele or genotype frequencies were found between the controls and the RSA women. The present study suggests that the IL-10 -1082 (G-->A) polymorphism is not a major genetic regulator in RSA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:40:12