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Titolo:
The efficacy of acquired humoral and cellular immunity in the prevention and therapy of experimental fungal infections
Autore:
Polonelli, L; Casadevall, A; Han, Y; Bernardis, F; Kirkland, TN; Matthews, RC; Adriani, D; Boccanera, M; Burnie, JP; Cassone, A; Conti, S; Cutler, JE; Frazzi, R; Gregory, C; Hodgetts, S; Illidge, C; Magliani, W; Rigg, G; Santoni, G;
Indirizzi:
Yeshiva Univ Albert Einstein Coll Med, Dept Med, Bronx, NY 10461 USA Yeshiva Univ Albert Einstein Coll Med Bronx NY USA 10461 nx, NY 10461 USA Univ Parma, Dept Patol & Med Lab, Sez Microbiol, I-43100 Parma, Italy UnivParma Parma Italy I-43100 Lab, Sez Microbiol, I-43100 Parma, Italy Ist Super Sanita, Dept Bacteriol & Med Mycol, I-00161 Rome, Italy Ist Super Sanita Rome Italy I-00161 iol & Med Mycol, I-00161 Rome, Italy Manchester Royal Infirm, Tec Pharma PLC, Manchester M13 9WL, Lancs, England Manchester Royal Infirm Manchester Lancs England M13 9WL , Lancs, England Univ Manchester, Infect Dis Res Grp, Manchester, Lancs, England Univ Manchester Manchester Lancs England Grp, Manchester, Lancs, England Montana State Univ, Dept Microbiol, Bozeman, MT 59717 USA Montana State Univ Bozeman MT USA 59717 Microbiol, Bozeman, MT 59717 USA UCSD Sch med, VA Med Ctr, San Diego, CA USA UCSD Sch med San Diego CA USA CSD Sch med, VA Med Ctr, San Diego, CA USA
Titolo Testata:
MEDICAL MYCOLOGY
, volume: 38, anno: 2000, supplemento:, 1
pagine: 281 - 292
SICI:
1369-3786(2000)38:<281:TEOAHA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
COCCIDIOIDES-IMMITIS ANTIGEN-2; PROLINE-RICH ANTIGEN; CANDIDA-ALBICANS; CRYPTOCOCCUS-NEOFORMANS; ANTIIDIOTYPIC ANTIBODIES; MONOCLONAL-ANTIBODIES; MURINE COCCIDIOIDOMYCOSIS; INVASIVE CANDIDIASIS; SYSTEMIC CANDIDIASIS; PROTECTIVE ANTIBODY;
Keywords:
antibody; Candida albicans; Coccidioides immitis; Cryptococcus neoformans;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
87
Recensione:
Indirizzi per estratti:
Indirizzo: Casadevall, A Yeshiva Univ Albert Einstein Coll Med, Dept Med, 1300 MorrisPk Ave, Bronx, NY 10461 USA Yeshiva Univ Albert Einstein Coll Med 1300 Morris Pk Ave Bronx NY USA 10461
Citazione:
L. Polonelli et al., "The efficacy of acquired humoral and cellular immunity in the prevention and therapy of experimental fungal infections", MED MYCOL, 38, 2000, pp. 281-292

Abstract

In the past two decades, numerous studies have documented the importance of acquired immunity for host defense against invasive fungal infections. There is widespread consensus in the field of medical mycology that cellular immunity is critical for successful host defense against fungi. However, inrecent years several studies have established the potential efficacy of humoral immunity in host protection against two major fungal pathogens: Candida albicans and Cryptococcus neoformans. For C. albicans, antibodies to mannan, proteases and a heat shock proteins have been associated with protection against infection. Furthermore, anti-idiotypic antibodies to antibodies recognizing killer toxin from Pichia anomala and mimicking natural anti-killer toxin receptor antibodies can protect against C. albicans and other microorganisms. For C. neoformans, antibodies to the capsular glucuronoxylomannan have been shown to mediate protection in animal models of infection. Vaccines that induce protective antibodies have been shown to protect againstexperimental C. albicans and C. neoformans infection. In contrast, humoralimmunity has not yet been demonstrated to mediate protection against Coccidioides immitis. For C. immitis, protection against infection is thought torely on T cell mediated immunity, and the emphasis is on identifying the antigens that stimulate protective cellular immune responses and several candidate vaccines have been identified. These results provide encouragement for the view that acquired immune responses can be mobilized for the prevention and treatment of fungal infections.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/08/18 alle ore 08:31:12