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Titolo:
Invasive aspergillosis
Autore:
Dupont, B; Richardson, M; Verweij, PE; Meis, JFGM;
Indirizzi:
Hop Necker, Inst Pasteur, Unite Mycol, F-75015 Paris, France Hop Necker Paris France F-75015 teur, Unite Mycol, F-75015 Paris, France Univ Helsinki, Haartman Inst, Dept Bacteriol & Immunol, Mycol Unit, FIN-00014 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00014 it, FIN-00014 Helsinki, Finland Univ Nijmegen, Med Ctr, Dept Med Microbiol, Nijmegen, Netherlands Univ Nijmegen Nijmegen Netherlands Med Microbiol, Nijmegen, Netherlands Canisus Wilhelmina Hosp, Dept Med Microbiol Publ Hlth & Infect Dis, Nijmegen, Netherlands Canisus Wilhelmina Hosp Nijmegen Netherlands Dis, Nijmegen, Netherlands
Titolo Testata:
MEDICAL MYCOLOGY
, volume: 38, anno: 2000, supplemento:, 1
pagine: 215 - 224
SICI:
1369-3786(2000)38:<215:IA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; LINKED-IMMUNOSORBENT-ASSAY; POLYMERASE CHAIN-REACTION; AMPHOTERICIN-B; PULMONARY ASPERGILLOSIS; FUNGAL-INFECTIONS; NEUTROPENIC PATIENTS; ITRACONAZOLE RESISTANCE; ANTIGEN-DETECTION; CANDIDA-ALBICANS;
Keywords:
chronic aspergillosis; laboratory diagnosis; resistance; solid organ transplantation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Dupont, B Hop Necker, Inst Pasteur, Unite Mycol, 149 Rue Sevres, F-75015 Paris, France Hop Necker 149 Rue Sevres Paris France F-75015 15 Paris, France
Citazione:
B. Dupont et al., "Invasive aspergillosis", MED MYCOL, 38, 2000, pp. 215-224

Abstract

Acute invasive aspergillosis (IA) is a devastating disease. Early diagnosis allowing an early treatment may improve the prognosis. However, this goalremains difficult to achieve. When diagnosis is confirmed it is often already too late. Galactomannan antigen detection and DNA detection are under clinical evaluation to improve early diagnosis and management of treatment. Despite antifungal treatment mortality rate is still high. Clinical resistance is more often due to the intensity of immunodepression than to high minimum inhibitory concentrations to antifungal agents; however, resistance toitraconazole may occur in rare instances. Beside acute IA, a chronic form of this infection may be seen as chronic necrotizing pulmonary aspergillosis or chronic invasive sinusitis. Other sites of infection have been described. The patients are immunocompetent or present minor alteration of their immunity or of anatomic structure of the infected site. Among patients with solid organ transplantation, lung and liver transplant patients are at the highest risk of developing IA. A high degree of awareness and efforts for an early diagnosis may participate to improve the poor prognosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 10:59:32