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Titolo:
THE NEOSTRIATAL MOSAIC - BASIS FOR THE CHANGING DISTRIBUTION OF NEUROKININ-1 RECEPTOR IMMUNOREACTIVITY DURING DEVELOPMENT
Autore:
ARDELT AA; KARPITSKIY VV; KRAUSE JE; ROTH KA;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT PATHOL,BOX 8118,660 S EUCLID AVE ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT PATHOL ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT ANAT & NEUROBIOL ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT MOL BIOL & PHARMACOL ST LOUIS MO 63110
Titolo Testata:
Journal of comparative neurology
fascicolo: 3, volume: 376, anno: 1996,
pagine: 463 - 475
SICI:
0021-9967(1996)376:3<463:TNM-BF>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBSTANCE-P RECEPTOR; CENTRAL NERVOUS-SYSTEM; RAT BASAL GANGLIA; CHOLINERGIC NEURONS; MAMMALIAN FOREBRAIN; PATTERN-FORMATION; DOPAMINE ISLANDS; PROTEIN-KINASE; STRIATAL COMPARTMENTALIZATION; INOSITOL 1,4,5-TRISPHOSPHATE;
Keywords:
TACHYKININS; NEOSTRIATUM; NEUROBIOLOGY; BASAL GANGLIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
65
Recensione:
Indirizzi per estratti:
Citazione:
A.A. Ardelt et al., "THE NEOSTRIATAL MOSAIC - BASIS FOR THE CHANGING DISTRIBUTION OF NEUROKININ-1 RECEPTOR IMMUNOREACTIVITY DURING DEVELOPMENT", Journal of comparative neurology, 376(3), 1996, pp. 463-475

Abstract

The pattern of neurokinin-1 receptor-like immunoreactivity (NK-1Rir) was mapped in perinatal and adult mouse striatum by using a new polyclonal antiserum. NK-1Rir was detected in the differentiating regions ofthe ganglionic eminences on embryonic day 12.5 (E12.5). NK-1Rir structures were enriched in the striatal patch compartment between E16.5 and approximately postnatal day 3 (P3); distributed more uniformly, within portions of both the patch and matrix compartments on P7; and enriched in the matrix compartment in the adult. Analysis of the phenotype of NK-1Rir cells on P2, P7, and in the adult suggested that cholinergic cells accounted for the majority of NK-1Rir cells early postnatally,with increasing contributions from somatostatinergic cells later postnatally. In the adult, approximately half of NK-1Rir cells were cholinergic and half were somatostatinergic. The transient enrichment of NK-1R-bearing cells and processes in the patch compartment which containscells that express substance P (SP), a putative ligand for the NK-1R,may be a consequence of compartment formation or may be functionally important for compartment development. (C) 1996 Wiley-Liss, Inc.

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Documento generato il 15/07/20 alle ore 08:23:50