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Titolo:
Role of GLUT1 gene in susceptibility to diabetic nephropathy in type 2 diabetes
Autore:
Grzeszczak, W; Moczulski, DK; Zychma, M; Zukowska-Szczechowska, E; Trautsolt, W; Szydlowska, I;
Indirizzi:
Silesian Sch Med, Dept Internal Med & Diabet, PL-41100 Zabrze, Poland Silesian Sch Med Zabrze Poland PL-41100 Diabet, PL-41100 Zabrze, Poland
Titolo Testata:
KIDNEY INTERNATIONAL
fascicolo: 2, volume: 59, anno: 2001,
pagine: 631 - 636
SICI:
0085-2538(200102)59:2<631:ROGGIS>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT MESANGIAL CELLS; GLUCOSE-TRANSPORTER GENE; MOLECULAR PHYSIOLOGY; EXPRESSION; MELLITUS; HEPG2; NIDDM; ASSOCIATION; POPULATION;
Keywords:
glucose transporter; NIDDM; XbaI polymorphism; chronic renal failure; hyperglycemia; microalbuminuria; proteinuria;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Grzeszczak, W Silesian Sch Med, Dept Internal Med & Diabet, Il 3 Maja 13-15, PL-41100 Zabrze, Poland Silesian Sch Med Il 3 Maja 13-15 Zabrze Poland PL-41100 and
Citazione:
W. Grzeszczak et al., "Role of GLUT1 gene in susceptibility to diabetic nephropathy in type 2 diabetes", KIDNEY INT, 59(2), 2001, pp. 631-636

Abstract

Background The XbaI polymorphism in the glucose transporter GLUT1 gene hasbeen implicated in the development of diabetic nephropathy in Chinese type2 diabetes patients. Methods. To examine whether the XbaI polymorphism is involved in the development of diabetic nephropathy in Caucasian type 2 diabetes patients, a large case control study was performed. The study group of 444 patients with type 2 diabetes consisted of three subgroups: 162 patients with normoalbuminuria (only patients with duration of type 2 diabetes of at least 10 years after diagnosis); 150 with microalbuminuria; and 132 subjects with persistent proteinuria or chronic renal failure (CRF). The polymerase chain reaction(PCR)-based genotyping of the XbaI polymorphism was performed in each subject. Results. The genotype distribution in the subgroups showed an increased frequency of the (+/+) genotype in patients with microalbuminuria (41%; OR 1.40, 95% CI, 0.89 to 2.24) and proteinuria/CRF (47%; OR 1.82, 95% CI, 1.13 to 2.93, P = 0.013) when compared with normoalbuminuria (33%). No differencein the genotype distribution was observed between type 2 diabetes patientsand healthy controls. Conclusions. The results of this study in Caucasian patients with type 2 diabetes indicate that the XbaI(-) allele in the GLUT1 gene protects againstthe development of diabetic nephropathy. Our results are in contrast to the case control study in Chinese patients with type 2 diabetes in which the presence of the XbaI(-) allele appeared to have a strong association with the development of diabetic nephropathy.

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Documento generato il 03/07/20 alle ore 01:51:22