Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Age-related differences in hippocampal extracellular fluid glucose concentration during behavioral testing and following systemic glucose administration
Autore:
McNay, EC; Gold, PE;
Indirizzi:
Univ Illinois, Dept Psychol, Champaign, IL 61820 USA Univ Illinois Champaign IL USA 61820 ept Psychol, Champaign, IL 61820 USA Yale Univ, Dept Psychol, New Haven, CT USA Yale Univ New Haven CT USAYale Univ, Dept Psychol, New Haven, CT USA
Titolo Testata:
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
fascicolo: 2, volume: 56, anno: 2001,
pagine: B66 - B71
SICI:
1079-5006(200102)56:2<B66:ADIHEF>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUS-ALTERNATION; ACETYLCHOLINE-RELEASE; MORPHINE INJECTIONS; MEMORY DEFICITS; ELDERLY HUMANS; RATS; MICRODIALYSIS; ENHANCEMENT; ATTENUATION; BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Gold, PE Univ Illinois, Dept Psychol, Champaign, IL 61820 USA Univ Illinois Champaign IL USA 61820 ol, Champaign, IL 61820 USA
Citazione:
E.C. McNay e P.E. Gold, "Age-related differences in hippocampal extracellular fluid glucose concentration during behavioral testing and following systemic glucose administration", J GERONT A, 56(2), 2001, pp. B66-B71

Abstract

Recent evidence indicates that the level of glucose in the brain's extracellular fluid (ECF) is not constant, as traditionally thought, but fluctuates. We determined the effect of aging on hippocampal ECF glucose before, during, and after spatial memory testing. Fischer-344 rats (24 months old) showed a greater decrease in ECF glucose than 3-month-old rats (48% vs 12%); the decrease seen in 24-month-old rats persisted for much longer following testing. These changes were associated with an age-related deficit in spontaneous alternation performance. Following systemic glucose administration, the decrease in ECF glucose was reversed in both aged and young rats, and performance in aged versus young rats following glucose administration did not differ. These findings suggest that increased susceptibility to depletionof ECF glucose in aged rats may contribute to age-related deficits in learning and memory and that administration of glucose may enhance memory by providing additional glucose to the brain at times of increased cognitive demand.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 13:13:36