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Titolo:
Age, fatigue, and excitation-contraction coupling in masseter muscles of rats
Autore:
Norton, MW; Mejia, W; McCarter, RJM;
Indirizzi:
Univ Texas, Hlth Sci Ctr, Dept Physiol, San Antonio, TX 78284 USA Univ Texas San Antonio TX USA 78284 pt Physiol, San Antonio, TX 78284 USA
Titolo Testata:
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
fascicolo: 2, volume: 56, anno: 2001,
pagine: B58 - B65
SICI:
1079-5006(200102)56:2<B58:AFAECI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
OUABAIN-H-3 BINDING-SITES; HUMAN SKELETAL-MUSCLE; CELLULAR MECHANISMS; INTRACELLULAR PH; NUMBER; INCREASES; RECOVERY; EXERCISE; ATPASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: McCarter, RJM Univ Texas, Hlth Sci Ctr, Dept Physiol, 7703 Floyd Curl Dr, San Antonio, TX 78284 USA Univ Texas 7703 Floyd Curl Dr San Antonio TX USA 78284 4 USA
Citazione:
M.W. Norton et al., "Age, fatigue, and excitation-contraction coupling in masseter muscles of rats", J GERONT A, 56(2), 2001, pp. B58-B65

Abstract

The purpose of this study was to determine if masseter muscle endurance changes with increasing age and, if so, to examine mechanisms of fatigue. Characteristics of fatigue were measured under isometric conditions using high-frequency stimulation of anterior deep masseter (ADM) muscles of male Fischer 344 rats, 5 to 24 months old, and fed a hard (HD) or a soft (SD) diet. Potentiating effects of caffeine on ADM muscle performance in vitro were also examined, Fatigability increased by 48% with age in muscles of HD rats. Muscles of SD rats were highly fatigable at all ages. Increased HD fatigability was associated with significantly decreased concentrations of Na+/K+-adenosine triphosphatase (22%) and decreased responsiveness to caffeine postfatigue (29%). The pH levels decreased similarly in fatigued muscles of ailgroups. We conclude that the age-related increase in fatigability is associated with alterations in excitation-contraction coupling mechanisms. However, differences between SD and HD on ADM muscles represent possible fiber-type transitions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 12:11:50