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Titolo:
Molecular and functional dissection of the H-2D(b)-restricted subdominant cytotoxic T-cell response to lymphocytic choriomeningitis virus
Autore:
Hudrisier, D; Riond, J; Gairin, JE;
Indirizzi:
CNRS, Inst Pharmacol & Biol Struct, Lab Immunopharmacol Struct, F-31400 Toulouse, France CNRS Toulouse France F-31400 opharmacol Struct, F-31400 Toulouse, France
Titolo Testata:
JOURNAL OF VIROLOGY
fascicolo: 5, volume: 75, anno: 2001,
pagine: 2468 - 2471
SICI:
0022-538X(200103)75:5<2468:MAFDOT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR HISTOCOMPATIBILITY COMPLEX; CLASS-I MOLECULES; VIRAL-INFECTION; RECEPTOR ANTAGONISTS; GLYCOPROTEIN EPITOPE; PEPTIDE COMPLEX; ANCHOR RESIDUES; H-2D(B); SELECTION; IDENTIFICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Gairin, JE CNRS, Inst Pharmacol & Biol Struct, Lab Immunopharmacol Struct,205 Route Narbonne, F-31400 Toulouse, France CNRS 205 Route Narbonne Toulouse France F-31400 ulouse, France
Citazione:
D. Hudrisier et al., "Molecular and functional dissection of the H-2D(b)-restricted subdominant cytotoxic T-cell response to lymphocytic choriomeningitis virus", J VIROLOGY, 75(5), 2001, pp. 2468-2471

Abstract

Infection of H-2(b) mice with lymphocytic choriomeningitis virus (LCMV) generates an H-2D(b)-restricted cytotoxic T-lymphocyte (CTL) response whose subdominant component is directed against the CP92-101 (CSANNSHHYI) epitope,The aim of this study was to identify the functional parameters accountingfor this subdominance, We found that the two naturally occurring (genetically encoded and posttranslationally modified) forms of LCMV GP92-101 were immunogenic, did not act as T-cell antagonists, and bound efficiently to butwere unable to form stable complexes with H-2D(b), a crucial factor for immunodominance. Thus, the H-2D(b)-restricted subdominant CTL response to LCMV resulted not from altered T-cell activation but from impaired major histocompatibility complex presentation properties.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 12:44:24