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Titolo:
Increased neutralization sensitivity of CD4-independent human immunodeficiency virus variants
Autore:
Kolchinsky, P; Kiprilov, E; Sodroski, J;
Indirizzi:
Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA DanaFarber Canc Inst Boston MA USA 02115 ol & AIDS, Boston, MA 02115 USA Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 munol & Infect Dis, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 h Med, Dept Pathol, Boston, MA 02115 USA
Titolo Testata:
JOURNAL OF VIROLOGY
fascicolo: 5, volume: 75, anno: 2001,
pagine: 2041 - 2050
SICI:
0022-538X(200103)75:5<2041:INSOCH>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
GP120 ENVELOPE GLYCOPROTEIN; RECOMBINANT SOLUBLE CD4; T-LYMPHOTROPIC RETROVIRUS; HTLV-III/LAV ENVELOPE; TYPE-1 GP120; CONFORMATIONAL-CHANGES; CHEMOKINE RECEPTORS; SYNCYTIUM FORMATION; HIV-1 ENTRY; AIDS VIRUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
96
Recensione:
Indirizzi per estratti:
Indirizzo: Sodroski, J Dana Farber Canc Inst, Dept Canc Immunol & AIDS, 44 Binney St,JFB 824, Boston, MA 02115 USA Dana Farber Canc Inst 44 Binney St,JFB 824 Boston MA USA 02115
Citazione:
P. Kolchinsky et al., "Increased neutralization sensitivity of CD4-independent human immunodeficiency virus variants", J VIROLOGY, 75(5), 2001, pp. 2041-2050

Abstract

Naturally occurring human immunodeficiency virus (HIV-1) variants require the presence of CD4 and specific chemokine receptors to enter a cell. In the laboratory, HIV-1 variants that are capable of bypassing CD4 and utilizing only the CCR5 chemokine receptor for virus entry have been generated. Here we report that these CD4-independent viruses are significantly more sensitive to neutralization by soluble CD4 and a variety of antibodies. The sameamino acid changes in the HIV-1 gp120 envelope glycoprotein determined CD4independence and neutralization sensitivity. The CD4-independent envelope glycoproteins exhibited higher affinity for antibodies against CD l-inducedgp120 epitopes but not other neutralizing ligands. The CD4-independent envelope glycoproteins did not exhibit increased lability relative to the wild-type envelope glycoproteins. The utilization of two receptors apparently allows HIV-1 to maintain a more neutralization-resistant state prior to engaging CD4 on the target cell, explaining the rarity of CD4 independence in wild-type HIV-1.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 15:53:29