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Titolo:
Undescended testis is accompanied by calcitonin gene related peptide accumulation within the sensory nucleus of the genitofemoral nerve in trans-scrotal rats
Autore:
Hrabovszky, Z; Farmer, PJ; Hutson, JM;
Indirizzi:
Royal Childrens Hosp, Res Inst, F Douglas Stephens Surg Res Lab, Melbourne, Vic, Australia Royal Childrens Hosp Melbourne Vic Australia , Melbourne, Vic, Australia
Titolo Testata:
JOURNAL OF UROLOGY
fascicolo: 3, volume: 165, anno: 2001,
pagine: 1015 - 1018
SICI:
0022-5347(200103)165:3<1015:UTIABC>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
TESTICULAR DESCENT; CRYPTORCHIDISM; GUBERNACULUM; DIFFERENTIATION; CONTRACTILITY; LOCALIZATION; INNERVATION; DENERVATION; RECEPTORS; MODELS;
Keywords:
testis; rats; calcitonin gene-related peptide; cryptorchidism; femoral nerve;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Hrabovszky, Z Royal Childrens Hosp, Res Inst, F Douglas Stephens Surg Res Lab, Melbourne, Vic, Australia Royal Childrens Hosp Melbourne Vic Australia ic, Australia
Citazione:
Z. Hrabovszky et al., "Undescended testis is accompanied by calcitonin gene related peptide accumulation within the sensory nucleus of the genitofemoral nerve in trans-scrotal rats", J UROL, 165(3), 2001, pp. 1015-1018

Abstract

Purpose: Recent data suggest that calcitonin gene related peptide (CGRP) released from the sensory branch of the genitofemoral nerve may regulate testicular descent. We studied the number of CGRP immunoreactive cells in the sensory nucleus of the genitofemoral nerve (L1 to L2 dorsal root ganglia) in cryptorchid trans-scrotal rats. Four-week-old trans-scrotal rats with unilateral undescended testis underwent bilateral genitofemoral nerve dissection and retrograde nerve labeling with the fluorescent dye 4,6-diamidino-2-phenylindole (DAPI). Animals were sacrificed 48 hours later and the L1 to L2 dorsal root ganglia were removed. Serial sections were obtained and double fluorescent labeled with antibody to CORP. Retrograde labeled and CORP immunoreactive cells were counted using an epi-fluorescent microscope. In the 6 male trans-scrotal rats evaluated we noted a mean plus or minus standard deviation of 1,272 +/- 98 retrograde labeled dorsal root ganglion cells ipsilateral to a fully descended testicle, including 98 +/- 34 that were also CGRP immunoreactive. On the side of the undescended testis there was a mean of 1,600 +/- 304 DAPI positive cells and 160 +/- 51 CGRP immunoreactive, DAPI labeled cells. The difference was significant (p <0.02). This study shows that in trans-scrotal rats the sensory nucleus of the genitofemoral nerve contains more CGRP immunoreactive cells ipsilateral to an undescended testis than on the contralateral side, highlighting the significance of CORP supply through the sensory branch of the genitofemoral nerve for testicular descent.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:35:46