Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The role of bladder afferent pathways in bladder hyperactivity induced by the intravesical administration of nerve growth factor
Autore:
Chuang, YC; Fraser, MO; Yu, YB; Chancellor, MB; de Groat, WC; Yoshimura, N;
Indirizzi:
Chang Gung Mem Hosp, Div Urol, Kaohsiung, Taiwan Chang Gung Mem Hosp Kaohsiung Taiwan Hosp, Div Urol, Kaohsiung, Taiwan Univ Pittsburgh, Sch Med, Dept Pharmacol, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 armacol, Pittsburgh, PA 15261 USA Univ Pittsburgh, Sch Med, Dept Urol, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA Sch Med, Dept Urol, Pittsburgh, PA USA Natl Yang Ming Univ, Sch Med, Dept Urol, Taipei 112, Taiwan Natl Yang MingUniv Taipei Taiwan 112 Med, Dept Urol, Taipei 112, Taiwan
Titolo Testata:
JOURNAL OF UROLOGY
fascicolo: 3, volume: 165, anno: 2001,
pagine: 975 - 979
SICI:
0022-5347(200103)165:3<975:TROBAP>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
IDIOPATHIC SENSORY URGENCY; INTERSTITIAL CYSTITIS; SPRAGUE-DAWLEY; WISTAR RATS; MICTURITION; INNERVATION; REFLEXES; WOMEN;
Keywords:
bladder; nerve growth factor; capsaicin; afferent pathways; rats, Wistar;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Chuang, YC Chang Gung Mem Hosp, Div Urol, 123 Ta Pei Rd, Kaohsiung, TaiwanChang Gung Mem Hosp 123 Ta Pei Rd Kaohsiung Taiwan ng, Taiwan
Citazione:
Y.C. Chuang et al., "The role of bladder afferent pathways in bladder hyperactivity induced by the intravesical administration of nerve growth factor", J UROL, 165(3), 2001, pp. 975-979

Abstract

Purpose: Interstitial cystitis, a chronic disease of the bladder, is characterized by urinary frequency, urgency and suprapubic pain. Nerve growth factor is a substance that may sensitize afferent nerves and induce bladder hyperactivity. It is often increased in the urine of patients with interstitial cystitis. We evaluated the role of A delta and C fiber afferents in thetype of bladder hyperactivity induced by the intravesical administration of nerve growth factor. Materials and Methods: A total of 22 Wistar and 8 Sprague-Dawley adult female rats were anesthetized with 1.2 gm./kg. urethane given subcutaneously. A transurethral catheter was inserted into the bladder. Some animals were pretreated with 125 mg./kg. capsaicin injected subcutaneously 4 days before nerve growth factor administration. Cystometry was performed by slowly filling the bladder at a rate of 0.04 ml. per minute for 15 minutes with a volume of up to 0.6 ml. Parameters measured included volume threshold and pressure threshold for inducing the micturition reflex, compliance, bladder contraction amplitude, number of contractions and the inter-contraction interval. Nerve growth factor (0.5 ml. of 20 mug./ml. in 10% dimethyl sulfoxide) or a vehicle solution (0.5 ml. of 10% dimethyl sulfoxide) was infused into the bladder through a transurethral catheter and retained for 1 hour. Results: In Wistar rats nerve growth factor increased the mean number of contractions by 111% versus controls (5.7 versus 2.7, p <0.05), and decreased the mean volume threshold by 41% (0.244 versus 0.412 ml., p <0.05). This effect of nerve growth factor was not detected in Sprague-Dawley rats. Capsaicin pretreatment increased the volume threshold by 59% but did not changenerve growth factor induced bladder hyperactivity. Conclusions: The intravesical application of nerve growth factor acutely induced bladder hyperactivity in Wistar but not in Sprague-Dawley rats. Because the C fiber afferent neurotoxin capsaicin did not change the effect of nerve growth factor, we believe that A delta afferent neurons have a major role in nerve growth factor induced bladder hyperactivity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 01:16:53