Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects of nickel chloride on human platelets: Enhancement of lipid peroxidation, inhibition of aggregation and interaction with ascorbic acid
Autore:
Chen, CY; Lin, TH;
Indirizzi:
Foo Yin Inst Technol, Dept Med Technol, Kaohsiung, Taiwan Foo Yin Inst Technol Kaohsiung Taiwan pt Med Technol, Kaohsiung, Taiwan Kaohsiung Med Univ, Sch Med Technol, Kaohsiung, Taiwan Kaohsiung Med UnivKaohsiung Taiwan Sch Med Technol, Kaohsiung, Taiwan
Titolo Testata:
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A
fascicolo: 6, volume: 62, anno: 2001,
pagine: 431 - 438
SICI:
1528-7394(200103)62:6<431:EONCOH>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIOXIDANT DEFENSE SYSTEMS; ALPHA-TOCOPHEROL; CARCINOGENESIS; TOXICITY; PLASMA; MICE; MECHANISM; RADICALS; LIVER; RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Chen, CY Foo Yin Inst Technol, Dept Med Technol, Kaohsiung, Taiwan Foo YinInst Technol Kaohsiung Taiwan chnol, Kaohsiung, Taiwan
Citazione:
C.Y. Chen e T.H. Lin, "Effects of nickel chloride on human platelets: Enhancement of lipid peroxidation, inhibition of aggregation and interaction with ascorbic acid", J TOX E H A, 62(6), 2001, pp. 431-438

Abstract

This study was undertaken to examine the effects of nickel ( Ni) on human platelet function. In a concentration-dependent manner, Ni significantly inhibited the function of platelet aggregation induced by collagen. The phenomenon of lipid peroxidation was involved as Ni significantly increased malondialdehyde ( MDA) levels with reduction in platelet reduced glutathione ( GSH) and alpha -tocopherol content. Further, platelet thromboxane B-2 formation was markedly inhibited and the levels of cyclic AMP were significantlyelevated by Ni. Treatment with ascorbic acid (Vit C) significantly loweredthe levels of MDA and increased the content of alpha -tocopherol and reduced GSH. Vit C also significantly increased platelet aggregation and thromboxane B2 when coincubated with Ni. Data show that Ni is toxic as evidenced by lipid peroxidative damage and inhibition of human platelet aggregation, but that ascorbic acid provides protection, at least partially, against thismetal.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:13:41