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Titolo:
Prevention of aortic and cardiac fibrosis by spironolactone in old normotensive rats
Autore:
Lacolley, P; Safar, ME; Lucet, B; Ledudal, K; Labat, C; Benetos, A;
Indirizzi:
Broussais Hosp, Dept Internal Med, Paris, France Broussais Hosp Paris France sais Hosp, Dept Internal Med, Paris, France Broussais Hosp, INSERM U337, Paris, France Broussais Hosp Paris FranceBroussais Hosp, INSERM U337, Paris, France
Titolo Testata:
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
fascicolo: 2, volume: 37, anno: 2001,
pagine: 662 - 667
SICI:
0735-1097(200102)37:2<662:POAACF>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; CONVERTING ENZYME-INHIBITION; BLOOD-VESSELS; ALDOSTERONE; COLLAGEN; HYPERTROPHY; MINERALOCORTICOIDS; REVERSAL; PRESSURE; ARTERIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Safar, ME Broussais Hosp, Dept Internal Med, Paris, France Broussais HospParis France Dept Internal Med, Paris, France
Citazione:
P. Lacolley et al., "Prevention of aortic and cardiac fibrosis by spironolactone in old normotensive rats", J AM COL C, 37(2), 2001, pp. 662-667

Abstract

OBJECTIVES Because the synthesis of aldosterone is mainly modulated by angiotensin II through type I receptor stimulation and because converting enzyme inhibition (CEI) does not modify aortic extracellular matrix in old normotensive rats, the aim of the present study was to determine whether inhibition of aldosterone formation was able to prevent aortic fibrosis in old Sprague-Dawley normotensive rats. BACKGROUND We have previously shown that long-term aldosterone antagonism prevents the age-related increase in aortic collagen accumulation in young spontaneously hypertensive rats, independent of blood pressure changes. In contrast, we reported that the positive effects of CEI in the prevention ofaortic collagen accumulation were related to the inhibition of angiotensinII actions on angiotensin II type I receptors. METHODS For this purpose, we studied the histomorphometric and stiffness (echo-tracking technique) changes of an eight-week treatment with the aldosterone antagonist spironolactone Dy comparison with placebo. RESULTS At the end of treatment, spironolactone in conscious animals did nut change intra-arterial blood pressure, aortic and carotid wall thickness,and cardiac weight. Cardiac collagen density and, to a lesser extent, carotid collagen and elastin densities and contents were significantly decreased in association with an increase of carotid distensibility. CONCLUSIONS These results show that in old normotensive rats, spironolactone can markedly prevent cardiac and, to a lesser extent, arterial fibrosis and improve arterial. stiffness, despite a lack of hypotensive effect. (C) 2001 by the American College of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 08:50:00