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Titolo:
Interaction between chemokines and oxidative stress: Possible pathogenic role in acute coronary syndromes
Autore:
Aukrust, P; Berge, RK; Ueland, T; Aaser, E; Damas, JK; Wikeby, L; Brunsvig, A; Muller, F; Forfang, K; Froland, SS; Gullestad, L;
Indirizzi:
Rikshosp, Dept Med, Sect Clin Immunol & Infect Dis, N-0027 Oslo, Norway Rikshosp Oslo Norway N-0027 in Immunol & Infect Dis, N-0027 Oslo, Norway Rikshosp, Dept Med, Internal Med Res Inst, N-0027 Oslo, Norway Rikshosp Oslo Norway N-0027 , Internal Med Res Inst, N-0027 Oslo, Norway Rikshosp, Dept Med, Endocrinol Sect, N-0027 Oslo, Norway Rikshosp Oslo Norway N-0027 pt Med, Endocrinol Sect, N-0027 Oslo, Norway Rikshosp, Dept Cardiol, N-0027 Oslo, Norway Rikshosp Oslo Norway N-0027Rikshosp, Dept Cardiol, N-0027 Oslo, Norway Haukeland Hosp, Div Clin Biochem, Dept Biol Clin, N-5021 Bergen, Norway Haukeland Hosp Bergen Norway N-5021 ept Biol Clin, N-5021 Bergen, Norway
Titolo Testata:
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
fascicolo: 2, volume: 37, anno: 2001,
pagine: 485 - 491
SICI:
0735-1097(200102)37:2<485:IBCAOS>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR-KAPPA-B; UNSTABLE ANGINA; INTERLEUKIN-8; EXPRESSION; ATHEROSCLEROSIS; HOMOCYSTEINE; STABILITY; DISEASE; PLAQUE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Aukrust, P Rikshosp, Dept Med, Sect Clin Immunol & Infect Dis, Sognsvannsveien 20, N-0027 Oslo, Norway Rikshosp Sognsvannsveien 20 Oslo Norway N-0027 27 Oslo, Norway
Citazione:
P. Aukrust et al., "Interaction between chemokines and oxidative stress: Possible pathogenic role in acute coronary syndromes", J AM COL C, 37(2), 2001, pp. 485-491

Abstract

OBJECTIVES We sought to study the relationships between chemokines and oxidative stress in acute coronary syndrome. BACKGROUND In view of existing knowledge on the participation of leukocytes and oxidative stress in the pathogenesis of acute coronary syndrome, we hypothesized that chemokines may play a role in recruiting and activating leukocytes in this disorder. METHODS The levels of chemokines and oxidative stress were studied in 38 patients with stable and 38 with unstable angina and in 20 controls. In separate in vitro experiments the effect of chemokines on reactive oxygen species in monocytes and the effect of antioxidants on chemokine levels in thesecells were also studied. RESULTS 1) Angina patients had raised serum levels of chemokines in both cross-sectional and longitudinal testing, with particularly high levels of interleukin (IL)-8, monocyte chemoattractant protein (MCP)-1 and macrophage inflammatory peptide (MIP)-1-alpha in unstable disease. 2) T cells, and particularly monocytes, seem to contribute to the raised IL-8, MCP-1 and MIP-l-alpha levels in unstable angina. 3) Concomitantly, and significantly correlated with MCP-1 and IL-8 levels, stable and particularly unstable angina patients had decreased plasma levels of antioxidants and increased lipid peroxidation, suggesting enhanced oxidative stress. 4) Monocyte chemoattractant protein-1 enhanced the generation of O-2(-) In monocytes from unstable angina patients, and the antioxidant glutathione-monoethyl ester suppressed the production of IL-8 and MCP-1 in these cells. CONCLUSIONS Our findings suggest an interaction between chemokines and oxidative stress in unstable angina. This interaction may represent a vicious circle involved in the pathogenesis of acute coronary syndromes. (C) 2001 by the American College of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:13:11