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Titolo:
Correlation of coronary calcification and angiographically documented stenoses in patients with suspected coronary artery disease: Results of 1,764 patients
Autore:
Haberl, R; Becker, A; Leber, A; Knez, A; Becker, C; Lang, C; Bruning, R; Reiser, M; Steinbeck, G;
Indirizzi:
Med Hosp 1, D-81241 Munich, Germany Med Hosp 1 Munich Germany D-81241Med Hosp 1, D-81241 Munich, Germany Univ Munich, Inst Radiol, Munich, Germany Univ Munich Munich GermanyUniv Munich, Inst Radiol, Munich, Germany
Titolo Testata:
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
fascicolo: 2, volume: 37, anno: 2001,
pagine: 451 - 457
SICI:
0735-1097(200102)37:2<451:COCCAA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
BEAM COMPUTED-TOMOGRAPHY; ELECTRON-BEAM; HEART-DISEASE; ATHEROSCLEROTIC LESIONS; STRESS ECHOCARDIOGRAPHY; METHODOLOGIC PROBLEMS; PERFUSION TOMOGRAPHY; CALCIUM SCORE; CHEST PAIN; DIAGNOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Haberl, R Med Hosp 1, Munchen Pasing,Steinerweg 5, D-81241 Munich, GermanyMed Hosp 1 Munchen Pasing,Steinerweg 5 Munich Germany D-81241 y
Citazione:
R. Haberl et al., "Correlation of coronary calcification and angiographically documented stenoses in patients with suspected coronary artery disease: Results of 1,764 patients", J AM COL C, 37(2), 2001, pp. 451-457

Abstract

Objectives This study correlated the electron beam computed tomographic (EBCT) calcium scores with the results of coronary angiography in symptomaticpatients in order to assess its value to predict or exclude significant coronary artery disease (CAD). Background Electron beam computed tomography is a sensitive method to detect coronary calcium. However, it is unclear whether it may play a role as afilter before invasive procedures in symptomatic patients. Methods A total of 1,764 patients (1,225 men and 539 women) with suspectedCAD from a single center were included in our study. All patients underwent calcium screening with EBCT (C150XP Imatron) and conventional coronary angiography. Results Fifty-six percent of men and 47% of women revealed significant coronary stenoses (greater than or equal to 50%). Total exclusion of coronary calcium (14% of the study group) was associated with an extremely low probability of stenosis (<1%). With calcium scores <greater than or equal to>20th, greater than or equal to 100th or greater than or equal to 75th percentile of age groups, the sensitivity to detect stenoses decreased to 97%, 93% and 81%, respectively, in men and to 98%, 82% and 76%, respectively, in women. At the same time, the specificity increased up to 77% in men and women. There was a significant difference in coronary calcium between men and women in all age groups; however, receiver-operating characteristic curves indicated that the test can be performed with equal accuracy in all of these subgroups. Conclusions Calcium screening with EBCT is a highly sensitive and moderately specific test to predict stenotic disease. Exclusion of coronary calciumdefines a substantial subgroup of patients, albeit symptomatic, with a very low probability of significant stenoses. (C) 2001 by the American Collegeof Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 05:38:52