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Titolo:
Immobilized metal complexes in porous organic hosts: Development of a material for the selective and reversible binding of nitric oxide
Autore:
Padden, KM; Krebs, JF; MacBeth, CE; Scarrow, RC; Borovik, AS;
Indirizzi:
Univ Kansas, Dept Chem, Lawrence, KS 66045 USA Univ Kansas Lawrence KS USA 66045 nsas, Dept Chem, Lawrence, KS 66045 USA Haverford Coll, Dept Chem, Haverford, PA 19041 USA Haverford Coll Haverford PA USA 19041 Dept Chem, Haverford, PA 19041 USA
Titolo Testata:
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
fascicolo: 6, volume: 123, anno: 2001,
pagine: 1072 - 1079
SICI:
0002-7863(20010214)123:6<1072:IMCIPO>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARBON-FIBER ELECTRODES; NITROSYL COMPLEXES; BLOODSUCKING INSECT; LASER PHOTOLYSIS; HEME PROTEIN; NO; PHOTOCHEMISTRY; COORDINATION; PHARMACOLOGY; COBALT(III);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Borovik, AS Univ Kansas, Dept Chem, Lawrence, KS 66045 USA Univ Kansas Lawrence KS USA 66045 hem, Lawrence, KS 66045 USA
Citazione:
K.M. Padden et al., "Immobilized metal complexes in porous organic hosts: Development of a material for the selective and reversible binding of nitric oxide", J AM CHEM S, 123(6), 2001, pp. 1072-1079

Abstract

Delivery of NO to specific targets is important in fundamental studies andtherapeutic applications. Various methods have been reported for delivery of NO in vivo and in vitro; however, there are few examples of systems thatreversibly bind NO. Reported herein is the development of a new polymer (P-1[Co-II]) that reversibly binds NO. P-1[Co-II] has a significantly higher affinity for NO compared to O-2, CO2, and CO. The polymer is synthesized bytemplate copolymerization methods and consists of a porous methacrylate network, containing immobilized four-coordinate Co-II sites. Binding of NO causes an immediate color change, indicating coordination of NO to the site-isolated Co-II centers. The formation of P-1[Co(NO)] has been confirmed by EPR, electronic absorbance, and X-ray absorption spectroscopies. Electronic and X-ray absorbance results for P-1[Co-II] and P-1[Co(NO)] show that the coordination geometry of the immobilized cobalt complexes are similar to those of their monomeric analogues and that NO binds directly to the cobalt centers. EPR spectra show that the binding of NO to P-1[Co-II] is reversible in the solid state; the axial EPR signal associated with the four-coordinate Co-II sites in P-1[Co-II] is quenched upon NO binding. At room temperature and atmospheric pressure, 40% conversion of P-1[Co(NO)] to P-1[Co-II] is achieved in 14 days; under vacuum at 120 degreesC this conversion is complete in similar to1 h. The binding of NO to P-1[Co-II] is also observed when the polymer is suspended in liquids, including water.

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Documento generato il 25/09/20 alle ore 09:03:11