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Titolo:
Towards a definition of "difference" in osteoarthritis
Autore:
Bellamy, N; Carr, A; Dougados, M; Shea, B; Wells, G;
Indirizzi:
Univ Queensland, Dept Med, St Lucia, Qld 4067, Australia Univ Queensland St Lucia Qld Australia 4067 St Lucia, Qld 4067, Australia
Titolo Testata:
JOURNAL OF RHEUMATOLOGY
fascicolo: 2, volume: 28, anno: 2001,
pagine: 427 - 430
SICI:
0315-162X(200102)28:2<427:TADO"I>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIRHEUMATIC DRUG TRIALS; CLINICAL-TRIALS; CONSENSUS DEVELOPMENT; OUTCOME MEASURES; KNEE; HIP;
Keywords:
discrimination; osteoarthritis; minimally clinically important difference;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Bellamy, N Univ Queensland, Royal Brisbane Hosp, Dept Med, C Floor,Clin Sci Bldg, Brisbane, Qld, Australia Univ Queensland C Floor,Clin Sci Bldg Brisbane Qld Australia a
Citazione:
N. Bellamy et al., "Towards a definition of "difference" in osteoarthritis", J RHEUMATOL, 28(2), 2001, pp. 427-430

Abstract

To assess existing information regarding detectable differences in osteoarthritis (OA), a systematic literature search was conducted up to December 1999. Thirty-three articles were considered methodologically relevant to thedefinition and categorization of detectable differences in OA. It was determined that the musculoskeletal literature contains a wealth of informationthat relates to observed changes, much of which is derived from the clinical trials literature, but there have been relatively few methodological studies that have systematically evaluated the nature, categorization, and relevance of the change. Furthermore, most of those that have been published take the perspective of an individual or groups of experts other than that of the patient. This summary of the current literature reveals that the diverse sources of information go part way towards developing an understanding of detectable differences and their importance in the area of OA research and clinical practice. Stakeholders' interests as well as factors that modulate perceptions of importance need to be taken under consideration. In particular, the patient's perspective of the importance of change at an individual level requires further evaluation. This area of clinical research is relatively underdeveloped, but there is considerable opportunity for progress.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 09:21:01