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Titolo:
Abundant expression of common cytokine receptor gamma chain (CD132) in rheumatoid joints
Autore:
Nishio, J; Kohsaka, H; Shimamura, T; Hamuro, J; Miyasaka, N;
Indirizzi:
Tokyo Med & Dent Univ, Grad Sch, Dept Bioregulatory Med & Rheumatol, Bunkyo Ku, Tokyo 1138519, Japan Tokyo Med & Dent Univ Tokyo Japan 1138519 unkyo Ku, Tokyo 1138519, Japan Ajinomoto Co Inc, Inst Basic Res, Kawasaki, Kanagawa, Japan Ajinomoto Co Inc Kawasaki Kanagawa Japan Res, Kawasaki, Kanagawa, Japan
Titolo Testata:
JOURNAL OF RHEUMATOLOGY
fascicolo: 2, volume: 28, anno: 2001,
pagine: 240 - 244
SICI:
0315-162X(200102)28:2<240:AEOCCR>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
IL-2 RECEPTOR; SYNOVIAL FIBROBLASTS; GROWTH-FACTOR; ARTHRITIS; INTERLEUKIN-2; FLUIDS; BLOOD; BETA;
Keywords:
common cytokine receptor gamma chain; CD132; rheumatoid arthritis; macrophage;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Nishio, J Tokyo Med & Dent Univ, Grad Sch, Dept Bioregulatory Med & Rheumatol, Bunkyo Ku, 1-5-45 Yushima, Tokyo 1138519, Japan Tokyo Med & Dent Univ 1-5-45 Yushima Tokyo Japan 1138519 Japan
Citazione:
J. Nishio et al., "Abundant expression of common cytokine receptor gamma chain (CD132) in rheumatoid joints", J RHEUMATOL, 28(2), 2001, pp. 240-244

Abstract

Objective. Activated macrophages upregulate surface expression of common cytokine receptor gamma chains (gammac, CD132), triggering of which induces secretion of proinflammatory cytokines. Rheumatoid synovial tissues containa number of macrophages that play a pathogenic role by secreting proinflammatory cytokines. We studied the expression of gammac in the rheumatoid synovial tissues. Methods. Cryosections of synovial tissues from patients with active rheumatoid arthritis (RA) or with osteoarthritis (OA) were stained with an anti-gammac Mab. Single-cell suspensions from the rheumatoid synovial tissues were stained with the same antibody and an anti-CD14 monoclonal antibody (Mab)for 2-color flow cytometric analysis. A soluble form of gammac in synovialfluids collected from rheumatoid or OA joints was quantitated by ELISA. Results. Rheumatoid synovial tissues, but not the OA tissues, expressed gammac at a high level. Flow cytometric analysis showed that gammac were expressed by virtually all CD14 positive synovial cells in RA. Synovial fluid derived from the rheumatoid joints contained a high concentration of solublegammac. Conclusion. Membrane bound and soluble forms of gammac are abundant in rheumatoid joints. They might play a complex role in the pathology of RA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:13:49