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Titolo:
Photodynamic therapy and diagnostic measurements of basal cell carcinomas using esterified and non-esterified delta-aminolevulinic acid
Autore:
Thompson, MS; Gustafsson, L; Palsson, S; Bendsoe, N; Stenberg, M; Klinteberg, CA; Andersson-Engels, S; Svanberg, K;
Indirizzi:
Univ Lund Hosp, Dept Oncol, SE-22185 Lund, Sweden Univ Lund Hosp Lund Sweden SE-22185 p, Dept Oncol, SE-22185 Lund, Sweden Lund Inst Technol, Dept Phys, S-22100 Lund, Sweden Lund Inst Technol Lund Sweden S-22100 l, Dept Phys, S-22100 Lund, Sweden Univ Lund, Inst Lab Med, Dept Microbiol Immunol & Glycobiol, Lund, Sweden Univ Lund Lund Sweden Dept Microbiol Immunol & Glycobiol, Lund, Sweden Univ Lund Hosp, Dept Dermatol, S-22185 Lund, Sweden Univ Lund Hosp Lund Sweden S-22185 , Dept Dermatol, S-22185 Lund, Sweden Univ Lund, Med Laser Ctr, Lund, Sweden Univ Lund Lund SwedenUniv Lund, Med Laser Ctr, Lund, Sweden
Titolo Testata:
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
fascicolo: 2, volume: 5, anno: 2001,
pagine: 147 -
SICI:
1088-4246(200102)5:2<147:PTADMO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
5-AMINOLEVULINIC ACID; PROTOPORPHYRIN-IX; ENDOGENOUS PROTOPORPHYRIN; IN-VIVO; FLUORESCENCE; PERFUSION; LIGHT;
Keywords:
laser-Doppler perfusion imaging; laser-induced fluorescence; protoporphyrin IX; delta-aminolevulinic acid; skin malignancies; thermal imaging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Svanberg, K Univ Lund Hosp, Dept Oncol, SE-22185 Lund, Sweden Univ Lund Hosp Lund Sweden SE-22185 l, SE-22185 Lund, Sweden
Citazione:
M.S. Thompson et al., "Photodynamic therapy and diagnostic measurements of basal cell carcinomas using esterified and non-esterified delta-aminolevulinic acid", J PORPHYR P, 5(2), 2001, pp. 147

Abstract

Various optical techniques were used to investigate relevant parameters involved in photodynamic therapy (PDT) of human basal cell carcinomas (BCCs). The aim of the study was to compare the diagnostic and therapeutic outcomewhen using topically applied methyl-esterified delta -aminolevulinic acid (ALA-ME) and delta -aminolevulinic acid (ALA). A total of 35 pathologicallyverified BCCs in 14 patients were investigated. A diode laser. emitting continuous light at 633 nm, was used to induce PDT. The diagnostic measurements were performed before, during, and after PDT. Laser-induced fluorescence(LIF) was used to monitor the build-up of the ALA/ALA-ME-induced protoporphyrin IX (PpIX), The superficial tissue perfusion was measured with laser-Doppler perfusion imaging (LDPI) and the temperature of the lesion and the surrounding tissue was imaged with an IR-camera. A clear demarcation betweenthe lesion and the normal skin was detected with LIF before the treatment for both PpIX precursors. The fluorescence measurements suggest that PpIX builds up to a higher degree and more selectively in the tumour following ALA-ME as compared to ALA. The LDPI measurements indicate a local transient restriction in blood perfusion immediately post-PDT. The measurement with the IR-camera revealed a temperature rise of about 1-2 degreesC during the treatment. Copyright (C) 2001 John Wiley & Sons, Ltd.

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Documento generato il 26/09/20 alle ore 12:08:52