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Titolo:
Determination of diclofenac sodium, flufenamic acid, indomethacin and ketoprofen by LC-APCI-MS
Autore:
Abdel-Hamid, ME; Novotny, L; Hamza, H;
Indirizzi:
Kuwait Univ, Hlth Sci Ctr, Fac Pharm, Dept Pharmaceut Chem, Safat 13110, Kuwait Kuwait Univ Safat Kuwait 13110 Dept Pharmaceut Chem, Safat 13110, Kuwait
Titolo Testata:
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
fascicolo: 4, volume: 24, anno: 2001,
pagine: 587 - 594
SICI:
0731-7085(200102)24:4<587:DODSFA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; PERFORMANCE LIQUID-CHROMATOGRAPHY; QUANTITATIVE MEASUREMENT; MASS-SPECTROMETRY; PLASMA; FORMS; SERUM; HPLC;
Keywords:
non-steroidal anti-inflammatory drugs; LC-MS; pharmaceutical analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Abdel-Hamid, ME Kuwait Univ, Hlth Sci Ctr, Fac Pharm, Dept Pharmaceut Chem, POB 24923, Safat 13110, Kuwait Kuwait Univ POB 24923 Safat Kuwait 13110 at 13110, Kuwait
Citazione:
M.E. Abdel-Hamid et al., "Determination of diclofenac sodium, flufenamic acid, indomethacin and ketoprofen by LC-APCI-MS", J PHARM B, 24(4), 2001, pp. 587-594

Abstract

A sensitive, selective and accurate high-performance liquid chromatography-mass spectrometry (LC-MS) assay for the determination of selected non-steroidal anti-inflammatory drugs (NSAIDs), namely diclofenac sodium (DIC), flufenamic acid (FLU), indomethacin (IND) and ketoprofen (KET), tither individually or in mixtures, was developed. The examined drugs were injected onto Shim-pack GLC-CN column and were eluted with a mobile phase consisting of acetonitrile and 20 mM ammonium acetate solution (5:1 v/v)/pH 7.4 at a flow rate 1 ml min(-1). The mass spectrometer. operated in the single ion monitoring mode, was programmed to admit the negative ions [M-H](-) at m/z 295.9 (DIC), 280.1 (FLU), 355.8 (IND) and 252.9 (KET), respectively. The calibration curves were linear (r greater than or equal to 0.9993) over the concentration range 50-300 ng ml(-1) (FLU, DIG) and 100-500 ng ml(-1) (KET, IND) with detection limits of 0.5-3.0 ng. The mean predicted concentrations for the analytes were in the range - 5.9 and 5.2% of the nominal concentrations. Within-day and between-day precision were in the range of 0.8-9.1% of the R.S.D. Mean recovery percentages of the individual compounds from laboratory-made mixtures and pharmaceutical formulations were (99.5-101.5%) and (100.6-102.2%), respectively. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 30/03/20 alle ore 19:41:03