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Titolo:
Nicotine effects on polymorphonuclear cell apoptosis and lipopolysaccharide-induced monocyte functions. A possible role in periodontal disease?
Autore:
Mariggio, MA; Guida, L; Laforgia, A; Santacroce, R; Curci, E; Montemurro, P; Fumarulo, R;
Indirizzi:
Fac Med, Dept Biomed Sci & Human Oncol, Bari, Italy Fac Med Bari ItalyFac Med, Dept Biomed Sci & Human Oncol, Bari, Italy Fac Med, Odontostomatol Inst, Bari, Italy Fac Med Bari ItalyFac Med, Odontostomatol Inst, Bari, Italy
Titolo Testata:
JOURNAL OF PERIODONTAL RESEARCH
fascicolo: 1, volume: 36, anno: 2001,
pagine: 32 - 39
SICI:
0022-3484(200102)36:1<32:NEOPCA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOKELESS TOBACCO; NEUTROPHIL; SMOKING; MACROPHAGES; INHIBITION; LEUKOCYTES; GINGIVAL; INFLAMMATION; INFECTION; INDUCTION;
Keywords:
nicotine; apoptosis; phagocytes; periodontal disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Fumarulo, R Policlin, Sezione Patol Gen, Dipartimento Sci Biomed, Piazza GCesare 11, I-70124 Bari, Italy Policlin Piazza G Cesare 11 Bari Italy I-70124 24 Bari, Italy
Citazione:
M.A. Mariggio et al., "Nicotine effects on polymorphonuclear cell apoptosis and lipopolysaccharide-induced monocyte functions. A possible role in periodontal disease?", J PERIOD RE, 36(1), 2001, pp. 32-39

Abstract

Apoptosis provides a mechanism for clearance of unwanted cells in a variety of situations in which programmed or physiological cell death occurs: butthe premature death of defensive cells could promote infection, inflammation and concomitant disease. We detected high values of apoptosis in polymorphonuclear cells (PMN) elicited from crevicular sulci of smokers affected by adult periodontitis. To learn more about the effects of nicotine on the periodontal environment, we studied its ability to modulate the apoptosis oftwo phagocytic lines, PMN and mononuclear cells, which are continuously recruited from gingival vessels to prevent or control plaque extension. Briefexposure of PMN to nicotine concentrations ranging from 0.01 to 0.3% shortened, in a dose-dependent relationship, the lag culture time required to observe at fluorescent microscopy the morphological traces of apoptosis. These observations were confirmed by specific tools of apoptosis: DNA fragmentation on gel electrophoresis and expression of the apoptosis-signaling receptor Fas/Apo-1. The apoptotic effect excited by nicotine on these first linedefensive cells may be an important feature of the pathogenesis of periodontal disease. As for mononuclear leukocytes, nicotine was unable to induce apoptotic modifications on cells observed up to 72 h culture time, but the:drug inhibited IL-IP release and procoagulant activity (PCA) expression. The: conflicting role played by these lipopolysaccharide (LPS)-induced monocyte functions in the inflammatory process is a further intrigue in the mechanism by which nicotine compromises the oral health.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 19:50:29