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Titolo:
The effect of spinal and systemic administration of indomethacin on zymosan-induced edema, mechanical hyperalgesia, and thermal hyperalgesia
Autore:
Turnbach, ME; Randich, A;
Indirizzi:
Univ Alabama, Dept Psychol, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 pt Psychol, Birmingham, AL 35294 USA
Titolo Testata:
JOURNAL OF PAIN
fascicolo: 1, volume: 2, anno: 2001,
pagine: 25 - 35
SICI:
1526-5900(200102)2:1<25:TEOSAS>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
METABOTROPIC GLUTAMATE RECEPTORS; ASPIRIN-LIKE DRUGS; CYCLOOXYGENASE INHIBITION; INDUCED INFLAMMATION; PROSTAGLANDIN E(2); RAT; COX-2; AMPA; COACTIVATION; ACTIVATION;
Keywords:
thermal hyperalgesia; mechanical hyperalgesia; indomethacin; spinal; systemic;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Turnbach, ME Univ Alabama, Dept Psychol, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 irmingham, AL 35294 USA
Citazione:
M.E. Turnbach e A. Randich, "The effect of spinal and systemic administration of indomethacin on zymosan-induced edema, mechanical hyperalgesia, and thermal hyperalgesia", J PAIN, 2(1), 2001, pp. 25-35

Abstract

Pretreatment with intraperitoneal (IP) indomethacin was used to determine whether indomethacin preferentially affected the development of edema and hyperalgesia to thermal and mechanical stimuli produced by injection of zymosan in the ispsilateral hindpaw of the rat. Indomethacin also was deliveredintrathecally (IT) either 30 minutes before or 4 hours after intraplantar zymosan to determine whether spinal prostaglandin production was important for the induction and/or maintenance of hyperalgesia. Zymosan alone produced a robust edema, a monophasic mechanical hyperalgesia, and a biphasic thermal hyperalgesia in the ipsilateral hindpaw. Systemic administration of indomethacin reduced zymosan-induced edema and increased thermal and mechanical response thresholds in the zymosan-injected paw. Systemic indomethacin did not affect thermal withdrawal response thresholds in the uninjected contralateral hindpaw of zymosan-treated rats, but significantly increased mechanical withdrawal thresholds of the uninjected contralateral paw of zymosan-treated rats. IT administration of indomethacin before the induction of hyperalgesia attenuated the development of zymosan-induced mechanical hyperalgesia, but did not affect the development of either zymosan-induced edema orthermal hyperalgesia. Once hyperalgesia was established, IT indomethacin also attenuated the mechanical hyperalgesia whereas it had no effect on thermal hyperalgesia or edema. These data suggest that peripheral, but not spinal prostaglandins contribute to the edema and development of thermal hyperalgesia produced by zymosan. In contrast, spinal prostaglandins contribute to the development and maintenance of mechanical hyperalgesia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 00:14:41