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Titolo:
Long-lasting inflammation and long-term hyperalgesia after subcutaneous formalin injection into the rat hindpaw
Autore:
Fu, KY; Light, AR; Maixner, W;
Indirizzi:
Univ N Carolina, Dept Cell & Mol Physiol, Dent Res Ctr, Chapel Hill, NC USA Univ N Carolina Chapel Hill NC USA ol, Dent Res Ctr, Chapel Hill, NC USA Beijing Med Univ, Sch Stomatol, Beijing 100083, Peoples R China Beijing Med Univ Beijing Peoples R China 100083 100083, Peoples R China
Titolo Testata:
JOURNAL OF PAIN
fascicolo: 1, volume: 2, anno: 2001,
pagine: 2 - 11
SICI:
1526-5900(200102)2:1<2:LIALHA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE FORMATION; CENTRAL-NERVOUS-SYSTEM; INDUCED TISSUE-INJURY; SUBSTANCE-P; SPINAL-CORD; ACTIVATED MICROGLIA; CYCLOOXYGENASE INHIBITION; PERSISTENT NOCICEPTION; PROSTAGLANDIN E(2); MESSENGER-RNA;
Keywords:
hyperalgesia; inflammation; pain; formalin; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Fu, KY Care Of Maixner W, Univ N Carolina, Sch Dent, Dent Res Ctr, Chapel Hill, NC 27599 USA Care Of Maixner W Chapel Hill NC USA 27599 apel Hill, NC 27599 USA
Citazione:
K.Y. Fu et al., "Long-lasting inflammation and long-term hyperalgesia after subcutaneous formalin injection into the rat hindpaw", J PAIN, 2(1), 2001, pp. 2-11

Abstract

Subcutaneous formalin injection is widely used as a nociceptive stimulus in the rat. This procedure evokes overt behaviors that last about 90 minutes. However, little is known about the duration of paw inflammation and alterations in pain sensitivity to noxious stimuli after 2 hours. We studied thenociceptive responses to thermal and mechanical stimuli 2 hours to 4 weeksafter formalin injection into the dorsal or plantar side of the hindpaw. Thirty-two adult male Sprague-Dawley rats were divided into 3 groups: In group I, 50 muL of 5% formalin was injected into the plantar side (n = 12); ingroup II, 50 muL of 5% formalin was injected into the dorsal side (n = 12); in group III, 50 muL saline was injected into the dorsal or plantar side of the hindpaw (n = 8). Nociceptive responses to thermal and mechanical stimuli applied to the dorsal or plantar surfaces of the injected and the contralateral hindpaws were recorded. The injection of formalin into the rat's hindpaw produced a hypoalgesic region around the injection site. In contrast, hyperalgesic responses to thermal and mechanical stimulation were induced on the opposite surface of the injected hindpaw as well as in the contralateral noninjected hindpaw. The hyperalgesic responses, which were observed2 hours after formalin administration, were enhanced 1 to 3 days after injection and lasted 3 to 4 weeks. These results suggest that peripheral inflammation after subcutaneous formalin injection produces a long-lasting sensitization. Possible mechanisms for these changes in nociception are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:50:25