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Titolo:
Early retardation of Tc-99m-DTPA radioaerosol transalveolar clearance in irradiated canine lung
Autore:
Suga, K; Alderson, PO; Mitra, A; Domingues, C; Rescigno, J; Smith, LG; Ogasawara, N; Matsunaga, N; Sasai, K;
Indirizzi:
Yamaguchi Univ, Sch Med, Dept Radiol, Ube, Yamaguchi 7558505, Japan Yamaguchi Univ Ube Yamaguchi Japan 7558505 Ube, Yamaguchi 7558505, Japan Yamaguchi Univ, Sch Med, Dept Pathol 2, Ube, Yamaguchi 7558505, Japan Yamaguchi Univ Ube Yamaguchi Japan 7558505 Ube, Yamaguchi 7558505, Japan Columbia Presbyterian Med Ctr, Dept Radiol, New York, NY 10032 USA Columbia Presbyterian Med Ctr New York NY USA 10032 ew York, NY 10032 USA Columbia Presbyterian Med Ctr, Dept Radiat Oncol, New York, NY 10032 USA Columbia Presbyterian Med Ctr New York NY USA 10032 ew York, NY 10032 USA
Titolo Testata:
JOURNAL OF NUCLEAR MEDICINE
fascicolo: 2, volume: 42, anno: 2001,
pagine: 292 - 299
SICI:
0161-5505(200102)42:2<292:EROTRT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
PULMONARY EPITHELIAL PERMEABILITY; BRONCHOALVEOLAR LAVAGE; RADIATION PNEUMONITIS; SYNTHETIC SURFACTANT; AEROSOLIZED SOLUTE; II CELLS; INJURY; DEPOSITION; CANCER; SYSTEM;
Keywords:
Tc-99m-DTPA; lung surfactant; pulmonary radioaerosol scintigraphy; alveolar permeability; radiation lung injury;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Suga, K Yamaguchi Univ, Sch Med, Dept Radiol, 1-1-1 Minamikogushi, Ube, Yamaguchi 7558505, Japan Yamaguchi Univ 1-1-1 Minamikogushi Ube Yamaguchi Japan 7558505 pan
Citazione:
K. Suga et al., "Early retardation of Tc-99m-DTPA radioaerosol transalveolar clearance in irradiated canine lung", J NUCL MED, 42(2), 2001, pp. 292-299

Abstract

The alteration of Tc-99m-labeled diethylenetriaminepentaacetic acid (DTPA)transalveolar clearance in an initial phase of radiation lung injury was experimentally investigated. Methods: Fourteen dogs were irradiated to the hemithorax with a single dose of 20 Gy. A DTPA radioaerosol study was performed before irradiation and on day 12 after irradiation. On day 14, the DTPAstudy was repeated again, with seven animals undergoing the study after inhalation of an aerosolized synthetic surfactant. The penetration index (P.I.) and clearance half-time (T-1/2) of DTPA were measured in each lung. To evaluate the changes in lung surfactant after irradiation, alveolar lipids were stained in the resected lungs (n = 14), and the amounts of alveolar surfactant phospholipid and protein were measured by a bronchoalveolar lavage study in another six irradiated dogs. Results: In all of the 14 irradiated animals. DTPA radioaerosol distributed uniformly throughout the lungs without significant changes in P.I. The T-1/2 values in irradiated lungs were significantly prolonged compared with the matched baseline values and those in nonirradiated lungs (P < 0.05 and 0.001, respectively). The aerosolized synthetic surfactant retarded the DTPA clearance both in the irradiated and in the nonirradiated lungs (P < 0.001) without significant changes in P.I. The histologic and bronchoalveolar lavage studies revealed an increase of alveolar surfactant materials in the irradiated lungs without substantial histologic changes in the alveolar structures. Conclusion: DTPA transalveolarclearance was retarded soon after irradiation. Increased alveolar surfactant may be partly responsible for this retarded DTPA clearance because the aerosolized synthetic surfactant also prolonged the clearance in nonirradiated lungs. A DTPA clearance test is sensitive for the early detection of radiation lung injury and seems helpful for clarifying the association of epithelial integrity changes and lung surfactant in radiation lung injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:43:16