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Titolo:
The lactic acid response to alkalosis in panic disorder: An integrative review
Autore:
Maddock, RJ;
Indirizzi:
Univ Calif Davis, Med Ctr, Dept Psychiat, Sacramento, CA 95817 USA Univ Calif Davis Sacramento CA USA 95817 ychiat, Sacramento, CA 95817 USA
Titolo Testata:
JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES
fascicolo: 1, volume: 13, anno: 2001,
pagine: 22 - 34
SICI:
0895-0172(200124)13:1<22:TLARTA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; BRAIN METABOLIC CHANGES; INTRACELLULAR PH; NEURONAL-ACTIVITY; HYPERVENTILATION; LACTATE; ATTACKS; GLYCOLYSIS; AGORAPHOBIA; PROPRANOLOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
75
Recensione:
Indirizzi per estratti:
Indirizzo: Maddock, RJ Univ Calif Davis, Med Ctr, Dept Psychiat, 2230 Stockton Blvd, Sacramento, CA 95817 USA Univ Calif Davis 2230 Stockton Blvd Sacramento CA USA 95817 SA
Citazione:
R.J. Maddock, "The lactic acid response to alkalosis in panic disorder: An integrative review", J NEUROP CL, 13(1), 2001, pp. 22-34

Abstract

Panic patients consistently show exaggerated, lactic acid response to alkalosis, whether produced by hyperventilation or by sodium lactate infusion. Understanding why this occurs may provide important clues to th pathogenesis of panic disorder. Although brain hypoxia from excessive hypocapnia-induced cerebral vasoconstriction is often cited as the mechanism of elevated brain lactic acid in panic disorder, studies of brain metabolism show that hypocapnia rarely fends to brain hypoxia. Increased lactic acid production isa normal response to intracellular alkalosis and to intracellular cyclic AMP. Thus, other possible mechanisms of the exaggerated lactic acid responsein panic disorder include a disturbance of mechanisms regulating intracellular pH and factors increasing intracellular cyclic AMP. Both mechanisms are consistent with the suffocation false alarm theory of panic disorder. This review suggests It theoretical fr framework for future magnetic resonancespectroscopy studies that can test some of the predictions of these competing models.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/05/20 alle ore 17:04:07