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Titolo:
Cerebral activation patterns in patients with writer's cramp: a functionalmagnetic resonance imaging study
Autore:
Preibisch, C; Berg, D; Hofmann, E; Solymosi, L; Naumann, M;
Indirizzi:
Univ Wurzburg, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 rzburg, D-97080 Wurzburg, Germany
Titolo Testata:
JOURNAL OF NEUROLOGY
fascicolo: 1, volume: 248, anno: 2001,
pagine: 10 - 17
SICI:
0340-5354(200101)248:1<10:CAPIPW>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
IDIOPATHIC TORSION DYSTONIA; FOCAL DYSTONIA; MOTOR; MOVEMENT; HEMIDYSTONIA; AREAS; FMRI; POTENTIALS; DISORDERS; NUCLEUS;
Keywords:
functional magnetic resonance imaging; writer's cramp; cerebral and cerebellar activation pattern;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Naumann, M Univ Wurzburg, Josef Schneider Str 11, D-97080 Wurzburg, Germany Univ Wurzburg Josef Schneider Str 11 Wurzburg Germany D-97080
Citazione:
C. Preibisch et al., "Cerebral activation patterns in patients with writer's cramp: a functionalmagnetic resonance imaging study", J NEUROL, 248(1), 2001, pp. 10-17

Abstract

Functional MRI (fMRI), visualizing changes in cerebral blood oxygenation, has to date not been performed either in patients with writer's cramp or inhealthy subjects during writing. We compared the cerebral and cerebellar activation pattern of 12 patients with writer's cramp during writing with a group of 10 healthy subjects performing the same tasks over 30-s periods ofrest or writing. Sixty echo planar imaging multislice datasets were analysed using SPM96 software. Data were analysed for each subject individually and groupwise for patients vs. controls. Healthy subjects showed a significant activation of the ipsilateral dentate nucleus, contralateral cerebellar hemisphere, contralateral primary sensorimotor cortex, and contralateral precentral gyrus during writing. Patients with writer's cramp showed significantly greater activation of the ipsilateral cerebellar hemisphere than controls. Also the activation in the primary sensorimotor cortex extended further caudally and anteriorly towards the premotor association area. Activation was observed in the thalamus during writing only among the patients. Our results indicate an increased basal ganglia output via the thalamus to the motor and premotor cortical areas in dystonia patients and support the notion of disinhibition of the motor cortex leading to cocontractions and dystonic postures.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 17:51:31