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Titolo:
The growth of the very large CD8(+) T cell clones in older mice is controlled by cytokines
Autore:
Ku, CC; Kappler, J; Marrack, P;
Indirizzi:
Natl Jewish Med & Res Ctr, Dept Immunol, Denver, CO 80207 USA Natl Jewish Med & Res Ctr Denver CO USA 80207 munol, Denver, CO 80207 USA Natl Jewish Med & Res Ctr, Howard Hughes Med Inst, Denver, CO 80207 USA Natl Jewish Med & Res Ctr Denver CO USA 80207 Inst, Denver, CO 80207 USA Univ Colorado, Sch Med, Dept Biochem & Mol Genet, Denver, CO 80207 USA Univ Colorado Denver CO USA 80207 ochem & Mol Genet, Denver, CO 80207 USA Univ Colorado, Sch Med, Dept Pharmacol, Denver, CO 80207 USA Univ Colorado Denver CO USA 80207 d, Dept Pharmacol, Denver, CO 80207 USA Univ Colorado, Sch Med, Dept Med, Denver, CO 80207 USA Univ Colorado Denver CO USA 80207 Sch Med, Dept Med, Denver, CO 80207 USA
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 4, volume: 166, anno: 2001,
pagine: 2186 - 2193
SICI:
0022-1767(20010215)166:4<2186:TGOTVL>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
RHEUMATOID-ARTHRITIS PATIENTS; MURINE IL-2 RECEPTOR; IN-VIVO; VIRUS-INFECTION; BETA(2)-MICROGLOBULIN-DEFICIENT MICE; MONOCLONAL-ANTIBODY; GENE-EXPRESSION; ELDERLY HUMANS; GAMMA-CHAIN; BETA-CHAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Marrack, P Natl Jewish Med & Res Ctr, Dept Immunol, 1400 Jackson St, Denver, CO 80207USA Natl Jewish Med & Res Ctr 1400 Jackson St Denver CO USA 80207 A
Citazione:
C.C. Ku et al., "The growth of the very large CD8(+) T cell clones in older mice is controlled by cytokines", J IMMUNOL, 166(4), 2001, pp. 2186-2193

Abstract

Older humans and mice frequently contain very large clones of CD8(+) T cells. In mice these cells are phenotypically very similar to memory CD8(+) T cells. Like memory CD8(+) T cells, most members of the clones are in continuous slow division, apparently independently of Ag stimulation, Proliferation of the CD8(+) clonal T cells is inhibited in mice treated with Ab to theIL-2R beta -chain that blocks signaling by either IL-2 or IL-15. However, inhibition of IL-2 increases the numbers of dividing clonal cells. Therefore, like normal memory CD8(+) T cells, expansion of the clones is driven by IL-15 and inhibited by IL-2 and is probably limited by the amounts of IL-15and IL-2 present in the host. Control by these two cytokines may account for the fact that, although the clones can be very large, they do not overwhelm or kill their hosts. Nevertheless the clonal cells compete successfullywith normal memory CD8(+) T cells for growth. Perhaps the clonal cells useIL-15 more effectively or are more resistant to the inhibitory effects of IL-2. Thus they might affect the immune response of their hosts by competing for factors that stimulate and inhibit normal CD8(+) memory T cells.

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Documento generato il 09/04/20 alle ore 07:31:56