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Titolo:
Cardiac safety parameters of olanzapine: Comparison with other atypical and typical antipsychotics
Autore:
Czekalla, J; Kollack-Walker, S; Beasley, CM;
Indirizzi:
Lilly Germany, Med CNS Div, D-61350 Bad Homburg, Germany Lilly Germany Bad Homburg Germany D-61350 , D-61350 Bad Homburg, Germany Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA Eli Lilly & CoIndianapolis IN USA 46285 Labs, Indianapolis, IN 46285 USA
Titolo Testata:
JOURNAL OF CLINICAL PSYCHIATRY
, volume: 62, anno: 2001, supplemento:, 2
pagine: 35 - 40
SICI:
0160-6689(2001)62:<35:CSPOOC>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
TORSADE-DE-POINTES; QT INTERVAL PROLONGATION; INTRAVENOUS HALOPERIDOL; PSYCHOTIC DISORDERS; ACUTE EXACERBATION; CRITICALLY ILL; SCHIZOPHRENIA; OVERDOSE; THIORIDAZINE; RISPERIDONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
72
Recensione:
Indirizzi per estratti:
Indirizzo: Czekalla, J Lilly Germany, Med CNS Div, Saalburgstr 153, D-61350 Bad Homburg, Germany Lilly Germany Saalburgstr 153 Bad Homburg Germany D-61350 any
Citazione:
J. Czekalla et al., "Cardiac safety parameters of olanzapine: Comparison with other atypical and typical antipsychotics", J CLIN PSY, 62, 2001, pp. 35-40

Abstract

Alterations of electrocardiogram results and cases of sudden cardiac deathhave been reported since the beginning of neuroleptic treatment. In particular, a temporal association exists between some antipsychotics and prolongation of the heart rate-corrected QT interval (QTc), an event that may increase the risk for developing a potentially fatal ventricular tachycardia arrhythmia known as torsades de pointes if it significantly exceeds normal intraindividual and interindividual variation. Although the incidence of serious adverse cardiac events in response to antipsychotic medications is relatively low, any possibility for the occurrence of cardiotoxicity warrants continued study. The present article reviews important differences among antipsychotic drugs in the potential for, and occurrence of, serious adverse cardiac outcomes and suggests that olanzapine, as therapeutically administered to patients with schizophrenia and related psychoses, does not contribute significantly to a QTc prolongation that could result in potentially fatal ventricular arrhythmias.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 20:02:21