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Titolo:
Demystified ... Adhesion molecule deficiencies
Autore:
Inwald, D; Davies, EG; Klein, N;
Indirizzi:
Inst Child Hlth, Portex Dept Anaesthesia, Intens Care & Resp Med & Immunobiol Unit, London WC1N 1EH, England Inst Child Hlth London England WC1N 1EH l Unit, London WC1N 1EH, England Great Ormond St Hosp Children NHS Trust, Dept Clin Immunol, London WC1N 3JF, England Great Ormond St Hosp Children NHS Trust London England WC1N 3JF England Inst Child Hlth, Immunobiol Unit, London WC1N 1EH, England Inst Child Hlth London England WC1N 1EH l Unit, London WC1N 1EH, England
Titolo Testata:
JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY
fascicolo: 1, volume: 54, anno: 2001,
pagine: 1 - 7
SICI:
1366-8714(200102)54:1<1:D.AMD>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLYCOPROTEIN-IIB-IIIA; ARG-GLY-ASP; LEUKOCYTE-ADHERENCE GLYCOPROTEINS; INTEGRIN SUBUNIT ASSOCIATION; BONE-MARROW TRANSPLANTATION; HUMAN-PLATELET ALLOANTIGENS; CELL-SURFACE EXPRESSION; AMINO-ACID SUBSTITUTION; GLANZMANN-THROMBASTHENIA; GAMMA-CHAIN;
Keywords:
leucocyte adhesion defect; Glanzmann's thrombasthenia; integrins;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
76
Recensione:
Indirizzi per estratti:
Indirizzo: Inwald, D Inst Child Hlth, Portex Dept Anaesthesia, Intens Care & Resp Med& Immunobiol Unit, 30 Guilford St, London WC1N 1EH, England Inst Child Hlth 30 Guilford St London England WC1N 1EH England
Citazione:
D. Inwald et al., "Demystified ... Adhesion molecule deficiencies", J CL PATH-M, 54(1), 2001, pp. 1-7

Abstract

The basic physiology of leucocyte emigration from the intravascular space into the tissues is now known to be dependent on a class of cell surface molecules that have come to be known as adhesion molecules. Many cell-cell interactions are dependent on adhesion and signal transduction via the various adhesion molecules, particularly the integrins. The study of the functions of these molecules has been enhanced by the development of blocking and activating monoclonal antibodies, knockout mice, and by the rare "experiments of nature" in the human population, in whom there is absence or dysfunction of one of the adhesion molecules. This review describes these leucocyte adhesion defects and discusses how they have provided important insights into the function of these molecules.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 09:05:07