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Titolo:
Speciation of platinum compounds: a review of recent applications in studies of platinum anticancer drugs
Autore:
Barefoot, RR;
Indirizzi:
Univ Toronto, Dept Geol, Toronto, ON M5S 3B1, Canada Univ Toronto TorontoON Canada M5S 3B1 Geol, Toronto, ON M5S 3B1, Canada
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY B
fascicolo: 2, volume: 751, anno: 2001,
pagine: 205 - 211
SICI:
1387-2273(20010225)751:2<205:SOPCAR>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIQUID-CHROMATOGRAPHY; CANCER-PATIENTS; MONOHYDRATED COMPLEX; LOBAPLATIN D-19466; MASS SPECTROMETRY; LIVER-FUNCTION; CISPLATIN; PLASMA; PHARMACOKINETICS; CARBOPLATIN;
Keywords:
reviews; platinum anticancer drugs;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Barefoot, RR Univ Toronto, Dept Geol, Toronto, ON M5S 3B1, Canada Univ Toronto Toronto ON Canada M5S 3B1 o, ON M5S 3B1, Canada
Citazione:
R.R. Barefoot, "Speciation of platinum compounds: a review of recent applications in studies of platinum anticancer drugs", J CHROMAT B, 751(2), 2001, pp. 205-211

Abstract

This is a review of investigations involving speciation studies of five important platinum-containing drugs used in cancer treatments. The information presented here is drawn from recent reports published during the period 1995-1999. The work includes detection, separations and identifications of degradation and biotransformation products. In addition, important information is reported on the number and nature of products of reactions of platinum anticancer drugs with thiol compounds. HPLC is employed effectively for separations of reaction products in speciation investigations. Information derived from speciation is very helpful in studies of pharmacokinetics as well as side effects and toxicities of the drugs as they are administered to patients. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 19:10:07