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Titolo:
Accumulation and aggregation of amyloid beta-protein in late endosomes of Niemann-Pick type C cells
Autore:
Yamazaki, T; Chang, TY; Haass, C; Ihara, Y;
Indirizzi:
Univ Tokyo, Fac Med, Dept Neuropathol, Bunkyo Ku, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 ropathol, Bunkyo Ku, Tokyo 1130033, Japan Dartmouth Med Sch, Dept Biochem, Hanover, NH 03755 USA Dartmouth Med Sch Hanover NH USA 03755 ept Biochem, Hanover, NH 03755 USA Univ Munich, Adolf Butenandt Inst, Dept Biochem, Lab Alzheimers Dis Res, D-80336 Munich, Germany Univ Munich Munich Germany D-80336 mers Dis Res, D-80336 Munich, Germany Japan Sci & Technol Corp, Core Res Evolut Sci & Technol, Kawaguchi 3320012, Japan Japan Sci & Technol Corp Kawaguchi Japan 3320012 awaguchi 3320012, Japan
Titolo Testata:
JOURNAL OF BIOLOGICAL CHEMISTRY
fascicolo: 6, volume: 276, anno: 2001,
pagine: 4454 - 4460
SICI:
0021-9258(20010209)276:6<4454:AAAOAB>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; INSOLUBLE MEMBRANE COMPARTMENT; PRECURSOR PROTEIN; CHOLESTEROL HOMEOSTASIS; ALZHEIMERS-DISEASE; SECRETASE CLEAVAGE; ENDOCYTIC PATHWAY; TRANSPORT; 3-BETA-<2-(DIETHYLAMINO)ETHOXY>ANDROST-5-EN-17-ONE; A-BETA-42(43);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Ihara, Y Univ Tokyo, Fac Med, Dept Neuropathol, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan Univ Tokyo 7-3-1 Hongo Tokyo Japan 1130033 Tokyo 1130033, Japan
Citazione:
T. Yamazaki et al., "Accumulation and aggregation of amyloid beta-protein in late endosomes of Niemann-Pick type C cells", J BIOL CHEM, 276(6), 2001, pp. 4454-4460

Abstract

There is growing evidence suggesting that cholesterol metabolism is linkedto susceptibility to Alzheimer's disease by influencing amyloid beta -protein (A beta) metabolism. However, the precise cellular linkage sites between cholesterol and A beta have not yet been clarified. To address this issue, we investigated Niemann-Pick type C (NPC) model cells and NPC mutant cells, which showed aberrant cholesterol trafficking. me observed a remarkable A beta accumulation in late endosomes of both NPC model cells and mutant cells where cholesterol accumulates and a significant accumulation in the NPCmouse brain. This A beta accumulation was independent of its constitutive secretion and production through an endocytic pathway. In addition, it is characterized by a marked predominance of A beta 42 and insolubility in SDS,suggesting the presence of aggregated A beta in late endosomes. Most importantly, A beta accumulation is coupled with the cholesterol levels in late endosomes. Thus, late endosomes of NPC cells are a novel pool of aggregatedA beta 42 as web as cholesterol, suggesting a direct interaction between aggregated A beta and cholesterol.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 21:22:21