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Titolo:
A review of randomized, controlled clinical trials in acute mania
Autore:
Keck, PE; Mendlwicz, J; Calabrese, JR; Fawcett, J; Suppes, T; Vestergaard, PA; Carbonell, C;
Indirizzi:
Univ Cincinnati, Coll Med, Dept Psychiat, Biol Psychiat Program, Cincinnati, OH 45267 USA Univ Cincinnati Cincinnati OH USA 45267 Program, Cincinnati, OH 45267 USA Free Univ Brussels, Lab Psychiat Res, Brussels, Belgium Free Univ Brussels Brussels Belgium Lab Psychiat Res, Brussels, Belgium Case Western Reserve Univ, Sch Med, Dept Psychiat, Mood Disorders Program,Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 ,Cleveland, OH 44106 USA Rush Presbyterian St Lukes Med Ctr, Dept Psychiat, Chicago, IL 60612 USA Rush Presbyterian St Lukes Med Ctr Chicago IL USA 60612 ago, IL 60612 USA Univ Texas, SW Med Ctr, Dept Psychiat, Dallas, TX USA Univ Texas Dallas TX USA exas, SW Med Ctr, Dept Psychiat, Dallas, TX USA Univ Aarhus, Hosp Psychiat, Aarhus, Denmark Univ Aarhus Aarhus DenmarkUniv Aarhus, Hosp Psychiat, Aarhus, Denmark San Carlos Univ Hosp, Dept Psychiat, Madrid, Spain San Carlos Univ Hosp Madrid Spain iv Hosp, Dept Psychiat, Madrid, Spain
Titolo Testata:
JOURNAL OF AFFECTIVE DISORDERS
, volume: 59, anno: 2000, supplemento:, 1
pagine: S31 - S37
SICI:
0165-0327(200009)59:<S31:ARORCC>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOUBLE-BLIND; LITHIUM-CARBONATE; MAINTENANCE TREATMENT; CALCIUM-ANTAGONISTS; ANTIMANIC EFFICACY; BIPOLAR DISORDER; CARBAMAZEPINE; CHLORPROMAZINE; CLONAZEPAM; PLACEBO;
Keywords:
acute mania; hypomania; electroconvulsive therapy; pharmacologic treatment;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Keck, PE Univ Cincinnati, Coll Med, Dept Psychiat, Biol Psychiat Program, POB 670559,231 Bethesda Ave, Cincinnati, OH 45267 USA Univ Cincinnati POB 670559,231 Bethesda Ave Cincinnati OH USA 45267
Citazione:
P.E. Keck et al., "A review of randomized, controlled clinical trials in acute mania", J AFFECT D, 59, 2000, pp. S31-S37

Abstract

This review considers the evidence supporting the use of somatic therapies(medications and electroconvulsive therapy) in the treatment of acute mania associated with bipolar disorder. Data from randomized, controlled clinical trials have established the efficacy of lithium, divalproex sodium, and carbamazepine in the treatment of acute mania. The use of combinations of mood stabilizers in the treatment of acute mania has not been well examined in controlled trials. Conventional antipsychotics and some atypical antipsychotics are frequently used as initial or adjunctive treatment. Similarly, benzodiazepines are frequently used as adjunctive agents. Preliminary data suggest that some calcium channel blockers and several anticonvulsants, e.g., lamotrigine, gabapentin, and topiramate, may have therapeutic value in the treatment of acute mania. In contrast, electroconvulsive therapy is generally accepted as being highly effective despite the lack of controlled evidence. (C) 2000 Elsevier Science B.V. All rights reserved.

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Documento generato il 05/04/20 alle ore 04:06:28