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Titolo:
INFLUENCE OF HEPATITIS-C VIRUS GENOTYPES AND HIV-INFECTION ON HISTOLOGICAL SEVERITY OF CHRONIC HEPATITIS-C
Autore:
GARCIASAMANIEGO J; SORIANO V; CASTILLA J; BRAVO R; MORENO A; CARBO J; INIGUEZ A; GONZALEZ J; MUNOZ F;
Indirizzi:
C LEOPOLDO ALAS CLARIN 2 MADRID 28035 SPAIN INST SALUD CARLOS III,CTR NACL EPIDEMIOL,CTR INVEST CLIN,HEPATOL UNITMADRID SPAIN INST SALUD CARLOS III,CTR NACL EPIDEMIOL,CTR INVEST CLIN,INFECT DIS UNIT MADRID SPAIN HOSP RAMON Y CAJAL,DEPT PATHOL E-28034 MADRID SPAIN
Titolo Testata:
The American journal of gastroenterology
fascicolo: 7, volume: 92, anno: 1997,
pagine: 1130 - 1134
SICI:
0002-9270(1997)92:7<1130:IOHVGA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; CHRONIC LIVER-DISEASE; CLINICAL IMPLICATIONS; SUBTYPES; HEMOPHILIACS; COINFECTION; INTERFERON; SYSTEM; SPAIN; RNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
J. Garciasamaniego et al., "INFLUENCE OF HEPATITIS-C VIRUS GENOTYPES AND HIV-INFECTION ON HISTOLOGICAL SEVERITY OF CHRONIC HEPATITIS-C", The American journal of gastroenterology, 92(7), 1997, pp. 1130-1134

Abstract

Objectives: The factors influencing the histological severity of chronic hepatitis C (CHC) have not been well established. We therefore investigated the effect of hepatitis C virus (HCV) genotypes and human immunodeficiency virus (HIV) infection on histological liver damage in acohort of intravenous drug users with CHC. Methods: We analyzed the histological activity score and the HCV genotypes in 59 HCV-RNA-positive patients with biopsy-proven CHC. Forty-eight (81%) of them had concomitant HIV infection with a CD4(+) cell count above 200 x 10(6) cells/L and an absence of AIDS-defining conditions. Multivariate analysis was performed to determine the features associated with the histologicalseverity. Results: Minimal/mild hepatitis was found in 16 patients (27%), moderate chronic hepatitis in 29 (49%), and severe chronic hepatitis in 14 (24%). Patients with HCV subtype 1b had a higher histological score than others (8.7 +/- 3.3 vs. 6.5 +/- 3.2, p = 0.012), either as single or mixed infections. In multivariate analysis, HIV-infected individuals had a higher score of piecemeal necrosis (OR = 21.7, p = 0.002) and a higher stage of fibrosis (OR = 17.9, p = 0.004) than patients without HIV infection. HIV infection and HCV genotype 1b were foundto be independent factors of histological severity. Conclusions: Liver damage in patients with CHC seems to be directly influenced by HCV subtypes. Infection by HCV subtype 1b is closely associated with more severe forms of liver pathology. Furthermore, the presence of HIV infection is an independent factor associated with more aggressive histological damage. In these patients, higher degrees of piecemeal necrosis and fibrosis are commonly seen.

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Documento generato il 07/07/20 alle ore 11:37:00