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Titolo:
Neuropsychiatric differences between Parkinson's disease with dementia andAlzheimer's disease
Autore:
Aarsland, D; Cummings, JL; Larsen, JP;
Indirizzi:
Rogaland Psychiat Hosp, Geriatr Psychiat Serv, N-4095 Stavanger, Norway Rogaland Psychiat Hosp Stavanger Norway N-4095 N-4095 Stavanger, Norway Univ Calif Los Angeles, Sch Med, Dept Neurol, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Univ Calif Los Angeles, Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA W Los Angeles Vet Affairs Med Ctr, Behav Neurosci Sect, Psychiat Serv, LosAngeles, CA 90073 USA W Los Angeles Vet Affairs Med Ctr Los Angeles CA USA90073 , CA 90073 USA Rogaland Psychiat Hosp, Dept Neurol, N-4095 Stavanger, Norway Rogaland Psychiat Hosp Stavanger Norway N-4095 N-4095 Stavanger, Norway
Titolo Testata:
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
fascicolo: 2, volume: 16, anno: 2001,
pagine: 184 - 191
SICI:
0885-6230(200102)16:2<184:NDBPDW>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE SUPRANUCLEAR PALSY; EXPLICIT MEMORY; LEWY BODIES; HUNTINGTONS; IMPAIRMENT; DISORDERS; DIAGNOSIS; SYMPTOMS; SIGNS;
Keywords:
Parkinson's disease; dementia; neuropsychiatric symptoms; Alzheimer's disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Aarsland, D Rogaland Psychiat Hosp, Geriatr Psychiat Serv, PO 1163 Hillevag, N-4095 Stavanger, Norway Rogaland Psychiat Hosp PO 1163 Hillevag Stavanger Norway N-4095
Citazione:
D. Aarsland et al., "Neuropsychiatric differences between Parkinson's disease with dementia andAlzheimer's disease", INT J GER P, 16(2), 2001, pp. 184-191

Abstract

Objective. To compare the profile of neuropsychiatric symptoms in patientswith Parkinson's disease with dementia (PDD) and patients with Alzheimer'sdisease (AD). Design. Cross-sectional survey of a population-based sample of patients with PDD and AD patients matched for age, sex, and Mini-Mental State Examination (MMSE) score. Method. Patients were diagnosed according to published criteria for PD andAD. The diagnosis of dementia in PD was made according to DSM-III-R, and was based on clinical interview of the patient and a relative, psychometric testing (including MMSE, Dementia Rating Scale and tests assessing memory, executive functions and visuospatial functioning) and physical examination. The Neuropsychiatric Inventory (NPI) was administered to all patients. Results. One or more psychiatric symptoms was reported in 95% of AD and 83% of PDD patients. Hallucinations were more severe in PD patients, while aberrant motor behavior, agitation, disinhibition, irritability, euphoria, and apathy were more severe in AD. In PDD, apathy was more common in mild Hoehn and Yahr stages, while delusions increased with more severe motor and cognitive disturbances. In PDD, only delusions correlated with the MMSE score. Conclusions. Neuropsychiatric symptoms are common and severe in patients with PDD, with important implications for the management of these patients. AD and PDD patients have different neuropsychiatric profiles, suggesting different underlying mechanisms. Cognitive impairment, psychopathology, and motor features progress independently in PDD patients Copyright (C) 2001 John Wiley Br Sons, Ltd.

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Documento generato il 22/01/20 alle ore 21:52:29