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Titolo:
Accuracy of contrast-enhanced computed tomography in the prediction of residual breast cancer after neoadjuvant chemotherapy
Autore:
Akashi-Tanaka, S; Fukutomi, T; Watanabe, T; Katsumata, N; Nanasawa, T; Matsuo, K; Miyakawa, K; Tsuda, H;
Indirizzi:
Natl Canc Ctr Hosp, Dept Surg Oncol, Chuo Ku, Tokyo 1040045, Japan Natl Canc Ctr Hosp Tokyo Japan 1040045 ol, Chuo Ku, Tokyo 1040045, Japan Natl Canc Ctr Hosp, Div Surg Oncol, Tokyo, Japan Natl Canc Ctr Hosp Tokyo Japan c Ctr Hosp, Div Surg Oncol, Tokyo, Japan Natl Canc Ctr Hosp, Div Med Oncol, Tokyo, Japan Natl Canc Ctr Hosp TokyoJapan nc Ctr Hosp, Div Med Oncol, Tokyo, Japan Natl Canc Ctr, Res Inst, Div Pathol, Tokyo 104, Japan Natl Canc Ctr Tokyo Japan 104 tr, Res Inst, Div Pathol, Tokyo 104, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF CANCER
fascicolo: 1, volume: 96, anno: 2001,
pagine: 66 - 73
SICI:
0020-7136(20010220)96:1<66:AOCCTI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREOPERATIVE CHEMOTHERAPY; INTRADUCTAL COMPONENT; CARCINOMA; SURGERY; TUMOR; WOMEN;
Keywords:
CT scan; breast cancer; neoadjuvant chemotherapy; breast-conserving surgery; diagnostic x-ray;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Akashi-Tanaka, S Natl Canc Ctr Hosp, Dept Surg Oncol, Chuo Ku, 1-1 Tsukiji5 chome, Tokyo 1040045, Japan Natl Canc Ctr Hosp 1-1 Tsukiji 5 chome Tokyo Japan 1040045
Citazione:
S. Akashi-Tanaka et al., "Accuracy of contrast-enhanced computed tomography in the prediction of residual breast cancer after neoadjuvant chemotherapy", INT J CANC, 96(1), 2001, pp. 66-73

Abstract

Determination of the extent of residual disease after neoadjuvant chemotherapy is sometimes inaccurate by conventional diagnostic methods. The purpose of this study was to evaluate the accuracy of contrast-enhanced computed tomography (CE-CT) in depicting the extent of residual carcinomas. Fifty-seven patients with breast carcinomas of 3 cm diameter or more received neoadjuvant chemotherapy with four cycles of AT (doxorubicin and docetaxel). Before surgery, the patients underwent clinical examination, mammogram (MMG), ultrasonography (US), and CE-CT. Thirteen patients were not evaluated by CE-CT before surgery. Enhancement patterns on CE-CT were classified into multiple spots, tumor and spots, solid tumor type, and no enhancement. When alltypes of cancers were included in the analysis, clinical examination showed the best correlation with the pathology of the extent of residual carcinomas. However, except in invasive lobular carcinoma (ILC) and inflammatory breast carcinoma (IBC), CE-CT showed the best correlation (R-boolean AND2 = 0.537). More than half of the residual microcalcifications on MMG after neoadjuvant chemotherapy suggested residual viable tumor. In conclusion, CE-CTis the most accurate noninvasive technique for identifying the extent of the residual carcinoma after neoadjuvant chemotherapy if cases of IBC and ILC are excluded. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:44:53