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Titolo:
Immune response of Drosophila melanogaster to infection with the flagellate parasite Crithidia spp.
Autore:
Boulanger, N; Ehret-Sabatier, L; Brun, R; Zachary, D; Bulet, P; Imler, JL;
Indirizzi:
Inst Biol Mol & Cellulaire, UPR 9022 CNRS, F-67000 Strasbourg, France InstBiol Mol & Cellulaire Strasbourg France F-67000 Strasbourg, France Swiss Trop Inst, CH-4002 Basel, Switzerland Swiss Trop Inst Basel Switzerland CH-4002 st, CH-4002 Basel, Switzerland
Titolo Testata:
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
fascicolo: 2, volume: 31, anno: 2001,
pagine: 129 - 137
SICI:
0965-1748(200102)31:2<129:IRODMT>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
RHODNIUS-PROLIXUS; ANTIMICROBIAL PEPTIDES; ANTIBACTERIAL PROTEINS; TRYPANOSOMA-CRUZI; INNATE IMMUNITY; AEDES-AEGYPTI; MIDGUT; HEMOLYMPH; MOSQUITO; SPECIFICITY;
Keywords:
insect immunity; Drosophila melanogaster; Crithidia; flagellate parasite; antimicrobial peptides;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Boulanger, N Inst Biol Mol & Cellulaire, UPR 9022 CNRS, 15 Rue Rene Descartes, F-67000 Strasbourg, France Inst Biol Mol & Cellulaire 15 Rue Rene Descartes Strasbourg France F-67000
Citazione:
N. Boulanger et al., "Immune response of Drosophila melanogaster to infection with the flagellate parasite Crithidia spp.", INSEC BIO M, 31(2), 2001, pp. 129-137

Abstract

Insects are able to recognize invading microorganisms and to mount an immune response to bacterial and fungal infections. Recently, the fruitfly Drosophila melanogaster has emerged as a promising invertebrate model to investigate innate immunity because of its well-characterized genetics. Insects are also Vectors of numerous parasites which can trigger an immune response. We have investigated the interaction of Drosophila melanogaster with the flagellate protozoan Crithidia spp. We show that a per os parasitic infection triggers the synthesis of several antimicrobial peptides. By reverse phase HPLC and mass spectrometry, peptides were shown to be present in the hemolymph and not in the gut tissue, suggesting the presence of immune messengers between the site of the infection, namely the gut, and the fat body, themain site of synthesis for antimicrobial peptides. Interestingly, we have identified one molecule which is specifically induced in the hemolymph after infection with Crithidia, but not with bacteria, suggesting that Drosophila can discriminate between pathogens. When flagellates were injected into the hemolymph, a low synthesis of antimicrobial peptides was observed together with phagocytosis of parasites by circulating hemocytes. The data presented here suggest that Drosophila-Crithidia spp. represents an interesting model to study host defense against protozoan parasites. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 03:15:36